Lower skin cancer risk in women with higher body mass index: the women's health initiative observational study.
Lower skin cancer risk in women with higher body mass index: the women's health initiative observational study.
- 2013
Available online from MWHC library: Nov 1991 - present (after 1 year)
The unclear relationship of obesity to incident melanoma and nonmelanoma skin cancer (NMSC) risks was evaluated in the large, geographically diverse longitudinal, prospective Women's Health Initiative (WHI) observational study. Risks of melanoma and NMSC in normal weight women were compared with risks in overweight [body mass index (BMI) = 25-29.0 kg/m(2)] and obese (BMI > 30 kg/m(2)) women, using Cox proportional hazards models for melanoma and logistic regression for NMSC. Over a mean 9.4 years of follow-up, there were 386 melanoma and 9,870 NSMC cases. Risk of melanoma did not differ across weight categories (P = 0.86), whereas in fully adjusted models, NMSC risk was lower in overweight [OR, 0.93; 95% confidence interval (CI), 0.89-0.99] and obese (OR, 0.85; 95% CI, 0.80-0.91) women (P < 0.001). Excess body weight was not associated with melanoma risk in postmenopausal women but was inversely associated with NMSC risk, possibly due to lower sun exposure in overweight and obese women. This supports previous work demonstrating the relationship between excess body weight and skin cancer risk. 2013 AACR.
English
1055-9965
*Body Mass Index
*Melanoma/ep [Epidemiology]
*Skin Neoplasms/ep [Epidemiology]
Age Factors
Aged
Cohort Studies
Female
Humans
Logistic Models
Middle Aged
Obesity/ep [Epidemiology]
Risk Factors
United States/ep [Epidemiology]
Women's Health
MedStar Health Research Institute
Journal Article
Research Support, N.I.H., Extramural
Available online from MWHC library: Nov 1991 - present (after 1 year)
The unclear relationship of obesity to incident melanoma and nonmelanoma skin cancer (NMSC) risks was evaluated in the large, geographically diverse longitudinal, prospective Women's Health Initiative (WHI) observational study. Risks of melanoma and NMSC in normal weight women were compared with risks in overweight [body mass index (BMI) = 25-29.0 kg/m(2)] and obese (BMI > 30 kg/m(2)) women, using Cox proportional hazards models for melanoma and logistic regression for NMSC. Over a mean 9.4 years of follow-up, there were 386 melanoma and 9,870 NSMC cases. Risk of melanoma did not differ across weight categories (P = 0.86), whereas in fully adjusted models, NMSC risk was lower in overweight [OR, 0.93; 95% confidence interval (CI), 0.89-0.99] and obese (OR, 0.85; 95% CI, 0.80-0.91) women (P < 0.001). Excess body weight was not associated with melanoma risk in postmenopausal women but was inversely associated with NMSC risk, possibly due to lower sun exposure in overweight and obese women. This supports previous work demonstrating the relationship between excess body weight and skin cancer risk. 2013 AACR.
English
1055-9965
*Body Mass Index
*Melanoma/ep [Epidemiology]
*Skin Neoplasms/ep [Epidemiology]
Age Factors
Aged
Cohort Studies
Female
Humans
Logistic Models
Middle Aged
Obesity/ep [Epidemiology]
Risk Factors
United States/ep [Epidemiology]
Women's Health
MedStar Health Research Institute
Journal Article
Research Support, N.I.H., Extramural