Markers of inflammation, metabolic risk factors, and incident heart failure in American Indians: the Strong Heart Study.
Markers of inflammation, metabolic risk factors, and incident heart failure in American Indians: the Strong Heart Study.
- 2012
Available online from MWHC library: 2001 - present
Inflammation may play a role in increased risk of heart failure (HF) that is associated with obesity, metabolic syndrome (MS), and diabetes. This study investigated associations between inflammatory markers, MS, and incident HF in a population with a high prevalence of diabetes, obesity, and MS. The cohort consisted of 3098 American Indians without prevalent cardiovascular disease who had C-reactive protein (CRP) and fibrinogen measured at the Strong Heart Study phase II examination. Independent associations between inflammatory markers, MS, and HF were analyzed by Cox hazard models. During a mean follow-up of 11 years, 218 participants developed HF. After the adjustment for cardiovascular risk factors, fibrinogen, (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.15-1.59) but not CRP (HR, 1.25; 95% CI, 0.97-1.32) remained a significant HF predictor. In individuals without diabetes, concomitant presence of MS and elevated CRP or fibrinogen increased HF risk (for MS and CRP: HR, 2.02; 95% CI, 0.95-4.31; for CRP and fibrinogen: HR, 1.75; 95% CI, 0.83-3.72). In a population with a high prevalence of obesity, MS, and diabetes, elevated CRP and fibrinogen increased HF risk. These associations are attenuated by the adjustments for conventional risk factors suggesting that inflammation acts in concert with metabolic and clinical risk factors in increasing HF risk. 2011 Wiley Periodicals, Inc.
English
1524-6175
*C-Reactive Protein/me [Metabolism]
*Fibrinogen/me [Metabolism]
*Heart Failure
*Inflammation
Aged
Biological Markers
Diabetes Mellitus/ep [Epidemiology]
Female
Health Surveys
Heart Failure/ep [Epidemiology]
Heart Failure/et [Etiology]
Heart Failure/me [Metabolism]
Humans
Indians, North American
Inflammation/co [Complications]
Inflammation/me [Metabolism]
Male
Metabolic Syndrome X/ep [Epidemiology]
Middle Aged
Obesity/ep [Epidemiology]
Prevalence
Proportional Hazards Models
Risk Factors
United States/eh [Ethnology]
United States/ep [Epidemiology]
MedStar Health Research Institute
MedStar Heart & Vascular Institute
Journal Article
Research Support, N.I.H., Extramural
Available online from MWHC library: 2001 - present
Inflammation may play a role in increased risk of heart failure (HF) that is associated with obesity, metabolic syndrome (MS), and diabetes. This study investigated associations between inflammatory markers, MS, and incident HF in a population with a high prevalence of diabetes, obesity, and MS. The cohort consisted of 3098 American Indians without prevalent cardiovascular disease who had C-reactive protein (CRP) and fibrinogen measured at the Strong Heart Study phase II examination. Independent associations between inflammatory markers, MS, and HF were analyzed by Cox hazard models. During a mean follow-up of 11 years, 218 participants developed HF. After the adjustment for cardiovascular risk factors, fibrinogen, (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.15-1.59) but not CRP (HR, 1.25; 95% CI, 0.97-1.32) remained a significant HF predictor. In individuals without diabetes, concomitant presence of MS and elevated CRP or fibrinogen increased HF risk (for MS and CRP: HR, 2.02; 95% CI, 0.95-4.31; for CRP and fibrinogen: HR, 1.75; 95% CI, 0.83-3.72). In a population with a high prevalence of obesity, MS, and diabetes, elevated CRP and fibrinogen increased HF risk. These associations are attenuated by the adjustments for conventional risk factors suggesting that inflammation acts in concert with metabolic and clinical risk factors in increasing HF risk. 2011 Wiley Periodicals, Inc.
English
1524-6175
*C-Reactive Protein/me [Metabolism]
*Fibrinogen/me [Metabolism]
*Heart Failure
*Inflammation
Aged
Biological Markers
Diabetes Mellitus/ep [Epidemiology]
Female
Health Surveys
Heart Failure/ep [Epidemiology]
Heart Failure/et [Etiology]
Heart Failure/me [Metabolism]
Humans
Indians, North American
Inflammation/co [Complications]
Inflammation/me [Metabolism]
Male
Metabolic Syndrome X/ep [Epidemiology]
Middle Aged
Obesity/ep [Epidemiology]
Prevalence
Proportional Hazards Models
Risk Factors
United States/eh [Ethnology]
United States/ep [Epidemiology]
MedStar Health Research Institute
MedStar Heart & Vascular Institute
Journal Article
Research Support, N.I.H., Extramural