The association of cord serum cytokines with neurodevelopmental outcomes.
The association of cord serum cytokines with neurodevelopmental outcomes.
- 2015
CONCLUSION: Cord serum IL-8, IL-1beta, and TNF-alpha levels in preterm infants are not associated with subsequent CP or NDD.Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. OBJECTIVE: To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD). RESULTS: Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1beta were more common in cord blood serum from infants with subsequent low MDI as compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1beta, and TNF-alpha) were not elevated with CP or low PDI. STUDY DESIGN: Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated preterm birth (PTB) for prevention of CP, with evaluation of surviving children at the age of 2. NDD was defined as a Bayley psychomotor developmental index (PDI) and/or mental developmental index (MDI)<70. Controls, defined as surviving children without CP and with Bayley PDI and MDI>85, were matched by race and gestational age. Cord serum was analyzed for interleukin-8 (IL-8) interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. Elevated cytokine levels were defined as>75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity, and sociodemographic differences.
English
0735-1631
*Cerebral Palsy/bl [Blood]
*Cytokines/bl [Blood]
*Developmental Disabilities/bl [Blood]
*Fetal Blood/me [Metabolism]
*Interleukin-1beta/bl [Blood]
*Interleukin-8/bl [Blood]
*Premature Birth/bl [Blood]
*Tumor Necrosis Factor-alpha/bl [Blood]
Adult
Case-Control Studies
Cerebral Palsy/di [Diagnosis]
Cerebral Palsy/pc [Prevention & Control]
Child Development
Child, Preschool
Developmental Disabilities/di [Diagnosis]
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Logistic Models
Magnesium Sulfate/tu [Therapeutic Use]
Pregnancy
Prognosis
Tocolytic Agents/tu [Therapeutic Use]
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology, Maternal-Fetal Medicine
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
CONCLUSION: Cord serum IL-8, IL-1beta, and TNF-alpha levels in preterm infants are not associated with subsequent CP or NDD.Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. OBJECTIVE: To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD). RESULTS: Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1beta were more common in cord blood serum from infants with subsequent low MDI as compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1beta, and TNF-alpha) were not elevated with CP or low PDI. STUDY DESIGN: Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated preterm birth (PTB) for prevention of CP, with evaluation of surviving children at the age of 2. NDD was defined as a Bayley psychomotor developmental index (PDI) and/or mental developmental index (MDI)<70. Controls, defined as surviving children without CP and with Bayley PDI and MDI>85, were matched by race and gestational age. Cord serum was analyzed for interleukin-8 (IL-8) interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. Elevated cytokine levels were defined as>75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity, and sociodemographic differences.
English
0735-1631
*Cerebral Palsy/bl [Blood]
*Cytokines/bl [Blood]
*Developmental Disabilities/bl [Blood]
*Fetal Blood/me [Metabolism]
*Interleukin-1beta/bl [Blood]
*Interleukin-8/bl [Blood]
*Premature Birth/bl [Blood]
*Tumor Necrosis Factor-alpha/bl [Blood]
Adult
Case-Control Studies
Cerebral Palsy/di [Diagnosis]
Cerebral Palsy/pc [Prevention & Control]
Child Development
Child, Preschool
Developmental Disabilities/di [Diagnosis]
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Logistic Models
Magnesium Sulfate/tu [Therapeutic Use]
Pregnancy
Prognosis
Tocolytic Agents/tu [Therapeutic Use]
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology, Maternal-Fetal Medicine
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural