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Epigenetics of progression of chronic kidney disease: fact or fantasy?.

Available in print through MWHC library: 1999 - present

Epigenetic modifications are important in the normal functioning of the cell, from regulating dynamic expression of essential genes and associated proteins to repressing those that are unneeded. Epigenetic changes are essential for development and functioning of the kidney, and aberrant methylation, histone modifications, and expression of microRNA could lead to chronic kidney disease (CKD). Here, epigenetic modifications modulate transforming growth factor beta signaling, inflammation, profibrotic genes, and the epithelial-to-mesenchymal transition, promoting renal fibrosis and progression of CKD. Identification of these epigenetic changes is important because they are potentially reversible and may serve as therapeutic targets in the future to prevent subsequent renal fibrosis and CKD. In this review we discuss the different types of epigenetic control, methods to study epigenetic modifications, and how epigenetics promotes progression of CKD. 2013 Elsevier Inc. All rights reserved.


English

ISSN: 0270-9295

Subjects--Topical Terms:
*Epigenesis, Genetic
*Renal Insufficiency, Chronic/ge [Genetics]
Animals
Disease Progression
DNA Methylation
Epithelial-Mesenchymal Transition
Gene-Environment Interaction
Humans
Inflammation/ge [Genetics]
MicroRNAs/ph [Physiology]
Organ Specificity

Subjects--Geographic Terms:
MedStar Health Research Institute

Index Terms--Function:
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't