Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium.

Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. - 2013

AIM AND METHODS: We hypothesised that BTs arise from transitional metaplasia near the tuboperitoneal junction which, when embedded in the ovary as Walthard cell nests, may progress to BTs. The aim of this study was to validate this hypothesis by a morphologic and immunohistochemical (IHC) analysis. BACKGROUND: Brenner tumours (BTs), like other epithelial ovarian tumours, are thought to develop from the ovarian surface epithelium. CONCLUSIONS: Our findings suggest a tubal origin of BTs through transitional metaplasia and Walthard cell nests, based on their anatomic proximity, similar IHC profile and the presence of cilia. In addition, we hypothesise a role of androgenic stimulation in the pathogenesis of BT, based on the IHC staining pattern of calretinin, inhibin and steroidogenic factor 1 expressed in the luteinised stromal cells surrounding the epithelial nests of the tumours, and AKR1C3 and androgen receptor expressed in both the epithelial and stromal components. Copyright 2013 Elsevier Ltd. All rights reserved. RESULTS: The IHC analysis revealed that fallopian tube secretory cells, transitional metaplasia, Walthard cell nests and the epithelial component of BTs shared a similar IHC profile, consistently expressing AKR1C3 (an enzyme involved in androgen biosynthesis) and androgen receptor, but not calretinin. The tumour stromal cells that immediately surrounded the epithelial nests showed strong expression of calretinin, inhibin and steroidogenic factor 1 (markers of steroidogenic cells) in the majority of BTs. Using a highly sensitive immunofluorescent staining method, we detected small groups of cilia in transitional metaplasia and Walthard cell nests, multifocal stretches of cilia and/or ciliated vacuoles in benign BTs and well-developed cilia in atypical proliferative BTs.


English

0959-8049


*Brenner Tumor/me [Metabolism]
*Epithelium/ch [Chemistry]
*Fallopian Tubes/ch [Chemistry]
*Ovarian Neoplasms/me [Metabolism]
3-Hydroxysteroid Dehydrogenases/me [Metabolism]
Brenner Tumor/pa [Pathology]
Calbindin 2/me [Metabolism]
Cilia/ch [Chemistry]
Cilia/pa [Pathology]
Epithelial Cells/me [Metabolism]
Epithelial Cells/pa [Pathology]
Epithelium/pa [Pathology]
Fallopian Tubes/pa [Pathology]
Female
Humans
Hydroxyprostaglandin Dehydrogenases/me [Metabolism]
Immunohistochemistry
Inhibins/me [Metabolism]
Metaplasia/me [Metabolism]
Metaplasia/pa [Pathology]
Microscopy, Fluorescence
Ovarian Neoplasms/pa [Pathology]
Ovary/ch [Chemistry]
Ovary/pa [Pathology]
Receptors, Androgen/me [Metabolism]
Steroidogenic Factor 1/me [Metabolism]
Stromal Cells/me [Metabolism]
Stromal Cells/pa [Pathology]


Pathology


Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

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