Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.
Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.
- 2013
This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (>20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ~15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved. 2013 WILEY PERIODICALS, INC.
English
0741-0395
*Antibodies, Bacterial/bl [Blood]
*Antibodies, Viral/bl [Blood]
*Coronary Artery Disease/ge [Genetics]
*Health Surveys
*Indians, North American/ge [Genetics]
*Infection/ge [Genetics]
*Infection/im [Immunology]
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Alaska
C-Reactive Protein/an [Analysis]
Chlamydophila pneumoniae/im [Immunology]
Chlamydophila pneumoniae/ip [Isolation & Purification]
Chromosomes, Human, Pair 15/ge [Genetics]
Chronic Disease
Coronary Artery Disease/mi [Microbiology]
Coronary Artery Disease/vi [Virology]
Cytomegalovirus/im [Immunology]
Cytomegalovirus/ip [Isolation & Purification]
Female
Genetic Linkage/ge [Genetics]
Genetic Predisposition to Disease/ge [Genetics]
Genome, Human/ge [Genetics]
Helicobacter pylori/im [Immunology]
Helicobacter pylori/ip [Isolation & Purification]
Herpesvirus 1, Human/im [Immunology]
Herpesvirus 1, Human/ip [Isolation & Purification]
Herpesvirus 2, Human/im [Immunology]
Herpesvirus 2, Human/ip [Isolation & Purification]
Humans
Immunoglobulin G/bl [Blood]
Infection/mi [Microbiology]
Infection/vi [Virology]
Lod Score
Male
Middle Aged
Pedigree
Seroepidemiologic Studies
Serologic Tests
Time Factors
Young Adult
MedStar Health Research Institute
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (>20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ~15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved. 2013 WILEY PERIODICALS, INC.
English
0741-0395
*Antibodies, Bacterial/bl [Blood]
*Antibodies, Viral/bl [Blood]
*Coronary Artery Disease/ge [Genetics]
*Health Surveys
*Indians, North American/ge [Genetics]
*Infection/ge [Genetics]
*Infection/im [Immunology]
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Alaska
C-Reactive Protein/an [Analysis]
Chlamydophila pneumoniae/im [Immunology]
Chlamydophila pneumoniae/ip [Isolation & Purification]
Chromosomes, Human, Pair 15/ge [Genetics]
Chronic Disease
Coronary Artery Disease/mi [Microbiology]
Coronary Artery Disease/vi [Virology]
Cytomegalovirus/im [Immunology]
Cytomegalovirus/ip [Isolation & Purification]
Female
Genetic Linkage/ge [Genetics]
Genetic Predisposition to Disease/ge [Genetics]
Genome, Human/ge [Genetics]
Helicobacter pylori/im [Immunology]
Helicobacter pylori/ip [Isolation & Purification]
Herpesvirus 1, Human/im [Immunology]
Herpesvirus 1, Human/ip [Isolation & Purification]
Herpesvirus 2, Human/im [Immunology]
Herpesvirus 2, Human/ip [Isolation & Purification]
Humans
Immunoglobulin G/bl [Blood]
Infection/mi [Microbiology]
Infection/vi [Virology]
Lod Score
Male
Middle Aged
Pedigree
Seroepidemiologic Studies
Serologic Tests
Time Factors
Young Adult
MedStar Health Research Institute
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't