Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study.
Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study.
- 2014
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSIONS: Prediabetes represents a high-risk state for CVD. Restoration of NGR and/or medical treatment of CVD risk factors can significantly reduce the estimated CVD risk in people with prediabetes.Copyright © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. OBJECTIVE: Restoration of normal glucose regulation (NGR) in people with prediabetes significantly decreases the risk of future diabetes. We sought to examine whether regression to NGR is also associated with a long-term decrease in cardiovascular disease (CVD) risk. RESEARCH DESIGN AND METHODS: The Framingham (2008) score (as an estimate of the global 10-year CVD risk) and individual CVD risk factors were calculated annually for the Diabetes Prevention Program Outcomes Study years 1-10 among those patients who returned to NGR at least once during the Diabetes Prevention Program (DPP) compared with those who remained with prediabetes or those in whom diabetes developed during DPP (N = 2,775). RESULTS: The Framingham scores by glycemic exposure did not differ among the treatment groups; therefore, pooled estimates were stratified by glycemic status and were adjusted for differences in risk factors at DPP baseline and in the treatment arm. During 10 years of follow-up, the mean Framingham 10-year CVD risk scores were highest in the prediabetes group (16.2%), intermediate in the NGR group (15.5%), and 14.4% in people with diabetes (all pairwise comparisons P < 0.05), but scores decreased over time for those people with prediabetes (18.6% in year 1 vs. 15.9% in year 10, P < 0.01). The lower score in the diabetes group versus other groups, a declining score in the prediabetes group, and favorable changes in each individual risk factor in all groups were explained, in part, by higher or increasing medication use for lipids and blood pressure.
English
0149-5992
*Blood Glucose/me [Metabolism]
*Cardiovascular Diseases/pc [Prevention & Control]
*Diabetes Mellitus, Type 2/pc [Prevention & Control]
*Hypoglycemic Agents/tu [Therapeutic Use]
*Prediabetic State/dt [Drug Therapy]
Blood Pressure
Cardiovascular Diseases/bl [Blood]
Cardiovascular Diseases/et [Etiology]
Diabetes Mellitus, Type 2/bl [Blood]
Diabetes Mellitus, Type 2/et [Etiology]
Female
Follow-Up Studies
Humans
Intervention Studies
Lipids/an [Analysis]
Male
Middle Aged
Multicenter Studies as Topic
Prediabetic State/bl [Blood]
Prediabetic State/co [Complications]
Randomized Controlled Trials as Topic
Remission Induction
Risk Factors
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSIONS: Prediabetes represents a high-risk state for CVD. Restoration of NGR and/or medical treatment of CVD risk factors can significantly reduce the estimated CVD risk in people with prediabetes.Copyright © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. OBJECTIVE: Restoration of normal glucose regulation (NGR) in people with prediabetes significantly decreases the risk of future diabetes. We sought to examine whether regression to NGR is also associated with a long-term decrease in cardiovascular disease (CVD) risk. RESEARCH DESIGN AND METHODS: The Framingham (2008) score (as an estimate of the global 10-year CVD risk) and individual CVD risk factors were calculated annually for the Diabetes Prevention Program Outcomes Study years 1-10 among those patients who returned to NGR at least once during the Diabetes Prevention Program (DPP) compared with those who remained with prediabetes or those in whom diabetes developed during DPP (N = 2,775). RESULTS: The Framingham scores by glycemic exposure did not differ among the treatment groups; therefore, pooled estimates were stratified by glycemic status and were adjusted for differences in risk factors at DPP baseline and in the treatment arm. During 10 years of follow-up, the mean Framingham 10-year CVD risk scores were highest in the prediabetes group (16.2%), intermediate in the NGR group (15.5%), and 14.4% in people with diabetes (all pairwise comparisons P < 0.05), but scores decreased over time for those people with prediabetes (18.6% in year 1 vs. 15.9% in year 10, P < 0.01). The lower score in the diabetes group versus other groups, a declining score in the prediabetes group, and favorable changes in each individual risk factor in all groups were explained, in part, by higher or increasing medication use for lipids and blood pressure.
English
0149-5992
*Blood Glucose/me [Metabolism]
*Cardiovascular Diseases/pc [Prevention & Control]
*Diabetes Mellitus, Type 2/pc [Prevention & Control]
*Hypoglycemic Agents/tu [Therapeutic Use]
*Prediabetic State/dt [Drug Therapy]
Blood Pressure
Cardiovascular Diseases/bl [Blood]
Cardiovascular Diseases/et [Etiology]
Diabetes Mellitus, Type 2/bl [Blood]
Diabetes Mellitus, Type 2/et [Etiology]
Female
Follow-Up Studies
Humans
Intervention Studies
Lipids/an [Analysis]
Male
Middle Aged
Multicenter Studies as Topic
Prediabetic State/bl [Blood]
Prediabetic State/co [Complications]
Randomized Controlled Trials as Topic
Remission Induction
Risk Factors