Improvement in All-Cause Mortality With Blood Pressure Control in a Group of US Veterans With Drug-Resistant Hypertension.
Improvement in All-Cause Mortality With Blood Pressure Control in a Group of US Veterans With Drug-Resistant Hypertension.
- 2016
Available online from MWHC library: 2001 - present
The current definition of drug-resistant hypertension includes patients with uncontrolled (URH) (taking >3 antihypertensive medications) and controlled hypertension (CRH; blood pressure [BP] <140/90 mm Hg) (taking >4 medications). The authors hypothesized that all-cause mortality is reduced when URH is controlled. Qualified patients followed at the Washington DC VA Medical Center were included. BPs were averaged for each year of follow-up. In 2006, among 2906 patients who met the criteria for drug-resistant hypertension, 628 had URH. During follow-up, 234 patients were controlled (group 1) and 394 patients remained uncontrolled (group 2). The mortality rate among patients with URH was 28% (110 of 394) and among patients with CRH was 13% (30 of 234), a 54% reduction (P<.01). Multivariate analysis identified independent predictors of mortality as uncontrolled HTN (hazard ratio, 2.5; 95% confidence interval, 1.67-3.75; P<.01), age (hazard ratio, 1.03; 95% confidence interval, 1.01-1.04; P<.01), and diabetes (hazard ratio, 1.46; 95% confidence interval, 1.04-2.05; P<.027). The authors conclude that controlling drug-resistant hypertension markedly reduces all-cause mortality. Copyright © 2015 Wiley Periodicals, Inc.
English
1524-6175
*Hypertension/dt [Drug Therapy]
*Hypertension/mo [Mortality]
*Veterans/sn [Statistics & Numerical Data]
Aged
Antihypertensive Agents/tu [Therapeutic Use]
Blood Pressure Determination/mt [Methods]
Blood Pressure/de [Drug Effects]
Drug Resistance
Female
Follow-Up Studies
Humans
Male
Middle Aged
Proportional Hazards Models
Retrospective Studies
United States/ep [Epidemiology]
MedStar Heart & Vascular Institute
Journal Article
Available online from MWHC library: 2001 - present
The current definition of drug-resistant hypertension includes patients with uncontrolled (URH) (taking >3 antihypertensive medications) and controlled hypertension (CRH; blood pressure [BP] <140/90 mm Hg) (taking >4 medications). The authors hypothesized that all-cause mortality is reduced when URH is controlled. Qualified patients followed at the Washington DC VA Medical Center were included. BPs were averaged for each year of follow-up. In 2006, among 2906 patients who met the criteria for drug-resistant hypertension, 628 had URH. During follow-up, 234 patients were controlled (group 1) and 394 patients remained uncontrolled (group 2). The mortality rate among patients with URH was 28% (110 of 394) and among patients with CRH was 13% (30 of 234), a 54% reduction (P<.01). Multivariate analysis identified independent predictors of mortality as uncontrolled HTN (hazard ratio, 2.5; 95% confidence interval, 1.67-3.75; P<.01), age (hazard ratio, 1.03; 95% confidence interval, 1.01-1.04; P<.01), and diabetes (hazard ratio, 1.46; 95% confidence interval, 1.04-2.05; P<.027). The authors conclude that controlling drug-resistant hypertension markedly reduces all-cause mortality. Copyright © 2015 Wiley Periodicals, Inc.
English
1524-6175
*Hypertension/dt [Drug Therapy]
*Hypertension/mo [Mortality]
*Veterans/sn [Statistics & Numerical Data]
Aged
Antihypertensive Agents/tu [Therapeutic Use]
Blood Pressure Determination/mt [Methods]
Blood Pressure/de [Drug Effects]
Drug Resistance
Female
Follow-Up Studies
Humans
Male
Middle Aged
Proportional Hazards Models
Retrospective Studies
United States/ep [Epidemiology]
MedStar Heart & Vascular Institute
Journal Article