Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications?.
Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications?.
- 2016
Available online from MWHC library: 1996 - present
CONCLUSIONS: Serum 25(OH)D levels did not significantly affect the likelihood of fracture healing complications requiring surgery or any nonorthopaedic injury-related surgery. DESIGN: Retrospective case series. INTERVENTION: All patients received 1000 IU of vitamin D3 and 1500 mg of calcium daily. Vitamin D deficient and insufficient patients also received 50,000 IU of ergocalciferol (vitamin D2) weekly until 25(OH)D levels normalized or fractures healed. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence. MAIN OUTCOME MEASUREMENTS: fracture complications and 25(OH)D levels. OBJECTIVES: To determine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the likelihood of postoperative complications and fracture reoperation rate in orthopaedic trauma patients receiving vitamin D and calcium supplementation. PATIENTS: All orthopaedic trauma patients-18 years or older-over a 20-month period were included with available initial and repeat 25(OH)D serum levels. In total, 201 patients met inclusion criteria. RESULTS: Fifteen patients experienced postoperative healing complications. There was no significant difference between initial (P = 0.92) or repeat (P = 0.91) 25(OH)D levels between patients with and without fracture healing complications. Twenty-eight patients required repeat orthopaedic surgery. There was no significant difference between initial (P = 0.62) or repeat (P = 0.18) 25(OH)D levels between patients who did or did not require repeat orthopaedic surgery. There was no significant difference between initial (P = 0.66) or repeat (P = 0.89) 25(OH)D levels between patients who did or did not require nonorthopaedic surgery. SETTING: Level I trauma center, Midwestern United States.
English
0890-5339
*Fractures, Bone/bl [Blood]
*Fractures, Bone/ep [Epidemiology]
*Postoperative Complications/bl [Blood]
*Postoperative Complications/ep [Epidemiology]
*Reoperation/ut [Utilization]
*Vitamin D/aa [Analogs & Derivatives]
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers/bl [Blood]
Bone Density Conservation Agents/tu [Therapeutic Use]
Calcium/tu [Therapeutic Use]
Female
Fractures, Bone/dt [Drug Therapy]
Humans
Male
Middle Aged
Missouri/ep [Epidemiology]
Postoperative Complications/pc [Prevention & Control]
Prevalence
Prognosis
Prospective Studies
Reproducibility of Results
Risk Assessment/mt [Methods]
Sensitivity and Specificity
Statistics as Topic
Treatment Outcome
Vitamin D/bl [Blood]
Vitamin D/tu [Therapeutic Use]
Young Adult
MedStar Washington Hospital Center
Surgery/Orthopaedic Surgery
Controlled Clinical Trial
Journal Article
Available online from MWHC library: 1996 - present
CONCLUSIONS: Serum 25(OH)D levels did not significantly affect the likelihood of fracture healing complications requiring surgery or any nonorthopaedic injury-related surgery. DESIGN: Retrospective case series. INTERVENTION: All patients received 1000 IU of vitamin D3 and 1500 mg of calcium daily. Vitamin D deficient and insufficient patients also received 50,000 IU of ergocalciferol (vitamin D2) weekly until 25(OH)D levels normalized or fractures healed. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence. MAIN OUTCOME MEASUREMENTS: fracture complications and 25(OH)D levels. OBJECTIVES: To determine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the likelihood of postoperative complications and fracture reoperation rate in orthopaedic trauma patients receiving vitamin D and calcium supplementation. PATIENTS: All orthopaedic trauma patients-18 years or older-over a 20-month period were included with available initial and repeat 25(OH)D serum levels. In total, 201 patients met inclusion criteria. RESULTS: Fifteen patients experienced postoperative healing complications. There was no significant difference between initial (P = 0.92) or repeat (P = 0.91) 25(OH)D levels between patients with and without fracture healing complications. Twenty-eight patients required repeat orthopaedic surgery. There was no significant difference between initial (P = 0.62) or repeat (P = 0.18) 25(OH)D levels between patients who did or did not require repeat orthopaedic surgery. There was no significant difference between initial (P = 0.66) or repeat (P = 0.89) 25(OH)D levels between patients who did or did not require nonorthopaedic surgery. SETTING: Level I trauma center, Midwestern United States.
English
0890-5339
*Fractures, Bone/bl [Blood]
*Fractures, Bone/ep [Epidemiology]
*Postoperative Complications/bl [Blood]
*Postoperative Complications/ep [Epidemiology]
*Reoperation/ut [Utilization]
*Vitamin D/aa [Analogs & Derivatives]
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers/bl [Blood]
Bone Density Conservation Agents/tu [Therapeutic Use]
Calcium/tu [Therapeutic Use]
Female
Fractures, Bone/dt [Drug Therapy]
Humans
Male
Middle Aged
Missouri/ep [Epidemiology]
Postoperative Complications/pc [Prevention & Control]
Prevalence
Prognosis
Prospective Studies
Reproducibility of Results
Risk Assessment/mt [Methods]
Sensitivity and Specificity
Statistics as Topic
Treatment Outcome
Vitamin D/bl [Blood]
Vitamin D/tu [Therapeutic Use]
Young Adult
MedStar Washington Hospital Center
Surgery/Orthopaedic Surgery
Controlled Clinical Trial
Journal Article