Patient characteristics in variable left ventricular recovery from Takotsubo syndrome.
Patient characteristics in variable left ventricular recovery from Takotsubo syndrome.
- 2018
Available in print through MWHC library: 2002 - present
BACKGROUND: Takotsubo syndrome (TTS) is a heart failure syndrome which is usually reversible. Factors associated with degree of recovery of left ventricular systolic function in TTS are poorly understood. CONCLUSION: Takotsubo patients with partial myocardial recovery were older, presented with longer QT intervals, and were more likely to have comorbid hypothyroidism. Copyright (c) 2017 Elsevier Inc. All rights reserved. MATERIALS AND METHODS: We conducted a retrospective analysis of 90 TTS patients treated at our institution from 2006 to 2014. Patients were grouped based on recovery of left ventricular ejection fraction (LVEF) on follow-up transthoracic echocardiogram as left ventricular ejection fraction <50% (partial group) or preserved ejection fraction >=50% (full group). Patient baseline characteristics, comorbidities, biomarkers, electrocardiography, and echocardiogram were collected. We also compared adverse events that occurred during hospitalization. RESULTS: In comparison to full recovery group patients (n=63), partial recovery patients (n=27) were older (76.9+/-13 vs. 70.6+/-13years; P=0.02) and had a higher prevalence of comorbid hypothyroidism (26% vs. 8%; P=0.02). A greater number of patients from the partial group were also taking levothyroxine replacement (22% vs. 3%; P=0.003). We found no significant between-group differences in type of triggering event or cardiac biomarker levels. QT interval was longer in the partial group (540.6+/-71msec vs. 460.7+/-35msec; P=0.01). Follow-up LVEF was 37.9+/-8% in the partial group and 58.0+/-4% in the full group (P<0.001). There were no statistically significant differences in length of stay or adverse events.
English
1878-0938
10.1016/j.carrev.2017.10.002 [doi] S1553-8389(17)30389-5 [pii]
*Stroke Volume
*Takotsubo Cardiomyopathy/pp [Physiopathology]
*Ventricular Function, Left
Action Potentials
Age Factors
Aged
Aged, 80 and over
Comorbidity
Echocardiography
Electrocardiography
Female
Heart Rate
Humans
Hypothyroidism/ep [Epidemiology]
Male
Middle Aged
Prevalence
Recovery of Function
Registries
Retrospective Studies
Takotsubo Cardiomyopathy/di [Diagnosis]
Takotsubo Cardiomyopathy/ep [Epidemiology]
Takotsubo Cardiomyopathy/th [Therapy]
Time Factors
United States/ep [Epidemiology]
MedStar Heart & Vascular Institute
MedStar Washington Hospital Center
Medicine/Internal Medicine
Journal Article
Available in print through MWHC library: 2002 - present
BACKGROUND: Takotsubo syndrome (TTS) is a heart failure syndrome which is usually reversible. Factors associated with degree of recovery of left ventricular systolic function in TTS are poorly understood. CONCLUSION: Takotsubo patients with partial myocardial recovery were older, presented with longer QT intervals, and were more likely to have comorbid hypothyroidism. Copyright (c) 2017 Elsevier Inc. All rights reserved. MATERIALS AND METHODS: We conducted a retrospective analysis of 90 TTS patients treated at our institution from 2006 to 2014. Patients were grouped based on recovery of left ventricular ejection fraction (LVEF) on follow-up transthoracic echocardiogram as left ventricular ejection fraction <50% (partial group) or preserved ejection fraction >=50% (full group). Patient baseline characteristics, comorbidities, biomarkers, electrocardiography, and echocardiogram were collected. We also compared adverse events that occurred during hospitalization. RESULTS: In comparison to full recovery group patients (n=63), partial recovery patients (n=27) were older (76.9+/-13 vs. 70.6+/-13years; P=0.02) and had a higher prevalence of comorbid hypothyroidism (26% vs. 8%; P=0.02). A greater number of patients from the partial group were also taking levothyroxine replacement (22% vs. 3%; P=0.003). We found no significant between-group differences in type of triggering event or cardiac biomarker levels. QT interval was longer in the partial group (540.6+/-71msec vs. 460.7+/-35msec; P=0.01). Follow-up LVEF was 37.9+/-8% in the partial group and 58.0+/-4% in the full group (P<0.001). There were no statistically significant differences in length of stay or adverse events.
English
1878-0938
10.1016/j.carrev.2017.10.002 [doi] S1553-8389(17)30389-5 [pii]
*Stroke Volume
*Takotsubo Cardiomyopathy/pp [Physiopathology]
*Ventricular Function, Left
Action Potentials
Age Factors
Aged
Aged, 80 and over
Comorbidity
Echocardiography
Electrocardiography
Female
Heart Rate
Humans
Hypothyroidism/ep [Epidemiology]
Male
Middle Aged
Prevalence
Recovery of Function
Registries
Retrospective Studies
Takotsubo Cardiomyopathy/di [Diagnosis]
Takotsubo Cardiomyopathy/ep [Epidemiology]
Takotsubo Cardiomyopathy/th [Therapy]
Time Factors
United States/ep [Epidemiology]
MedStar Heart & Vascular Institute
MedStar Washington Hospital Center
Medicine/Internal Medicine
Journal Article