Reference ranges for rotational thromboelastometry in male Sprague Dawley rats.
Reference ranges for rotational thromboelastometry in male Sprague Dawley rats.
- 2017
Available online through MWHC library: 2003 - present
Background: A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system. Conclusions: These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies. Methods: Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM delta hemostasis analyzer with the EXTEM test. Results: The following ranges, presented as the 2.5-97.5 percentiles, were established: CT [18-77], CFT [20-80], alpha [73-86], MCF [53-70], and ML [1-22], along with others.
English
1477-9560
10.1186/s12959-017-0154-0 [doi] 154 [pii] PMC5747092 [pmc]
PubMed-not-MEDLINE -- Not indexed
MedStar Health Research Institute
MedStar Washington Hospital Center
Firefighters' Burn and Surgical Research Laboratory
Surgery
Journal Article
Available online through MWHC library: 2003 - present
Background: A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system. Conclusions: These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies. Methods: Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM delta hemostasis analyzer with the EXTEM test. Results: The following ranges, presented as the 2.5-97.5 percentiles, were established: CT [18-77], CFT [20-80], alpha [73-86], MCF [53-70], and ML [1-22], along with others.
English
1477-9560
10.1186/s12959-017-0154-0 [doi] 154 [pii] PMC5747092 [pmc]
PubMed-not-MEDLINE -- Not indexed
MedStar Health Research Institute
MedStar Washington Hospital Center
Firefighters' Burn and Surgical Research Laboratory
Surgery
Journal Article