Platelet count and total and cause-specific mortality in the Women's Health Initiative.
Platelet count and total and cause-specific mortality in the Women's Health Initiative.
- 2017
CONCLUSIONS: In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality. Copyright (c) 2017 Elsevier Inc. All rights reserved. METHODS: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count. PURPOSE: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality. RESULTS: Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers.
English
1047-2797
*Cause of Death
*Mortality
*Platelet Count
Aged
Coronary Disease/bl [Blood]
Coronary Disease/mo [Mortality]
Female
Humans
Middle Aged
Neoplasms/bl [Blood]
Neoplasms/mo [Mortality]
Platelet Count/sn [Statistics & Numerical Data]
Proportional Hazards Models
Women's Health/sn [Statistics & Numerical Data]
Washington Cancer Institute
Journal Article
CONCLUSIONS: In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality. Copyright (c) 2017 Elsevier Inc. All rights reserved. METHODS: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count. PURPOSE: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality. RESULTS: Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers.
English
1047-2797
*Cause of Death
*Mortality
*Platelet Count
Aged
Coronary Disease/bl [Blood]
Coronary Disease/mo [Mortality]
Female
Humans
Middle Aged
Neoplasms/bl [Blood]
Neoplasms/mo [Mortality]
Platelet Count/sn [Statistics & Numerical Data]
Proportional Hazards Models
Women's Health/sn [Statistics & Numerical Data]
Washington Cancer Institute
Journal Article