IgG4-related disease involving the esophagus: a clinicopathological study.
IgG4-related disease involving the esophagus: a clinicopathological study.
- 2017
Immunoglobulin G4 (IgG4)-related disease is a recently coined systemic disease characterized by specific histopathologic findings of an intense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis in the presence of predominant IgG4-positive plasma cells. Although IgG4-related disease has been described in many organs, involvement of the esophagus is very rare. In this study, we describe the clinicopathologic characteristics of eight patients with IgG4-related esophagitis. We evaluated chronic esophagitis specimens with lymphoplasmacytic infiltrate obtained over the past 6 years (from January 2011 to February 2017) using a chart review, pathologic examination, and IgG4 immunohistochemical staining. The diagnoses of the specimens were either confirmed as IgG4-related esophagitis (IgG4-RE) or chronic esophagitis, not otherwise specified (CENOS), and the clinicopathologic data from each group were compared. Eight patients were diagnosed with IgG4-RE and 10 controls were identified and diagnosed with CENOS. In the IgG4-RE group, esophageal strictures were identified in three patients, two patients had postmyotomy treated achalasia, one patient had erosive esophagitis and another presented with an esophageal nodule. Only one patient had an unremarkable mucosa on endoscopy. In the CENOS group, four patients had esophageal strictures, six had erosive esophagitis, one patient had mild esophagitis. The IgG4-RE group had significantly higher numbers of IgG4-positive plasma cells (66.9 +/- 21.9 vs. 4.7 +/- 2.4 per high power field; P< 0.001) and a greater IgG4: IgG ratio 0.76 +/- 0.13 vs. 0.06 +/- 0.05; P< 0.001) when compared to CENOS patients. Two of the patients with recurrent esophageal strictures in the IgG4-RE group showed initial response to steroid therapy and are currently on immunosuppressive therapy which has significantly reduced the need for multiple esophageal dilatations. The presentation of IgG4-related esophageal disease can vary and the key to diagnosis is dependent on histopathology. These observations highlight the need for IgG4 immunohistochemical staining of esophageal biopsies especially in patients with mucosal ulceration, chronic inflammation, and plasmacytosis on biopsy. This will prevent unwarranted esophagectomies and failed medical treatment due to lack of recognition of this entity. Copyright (c) The Authors 2017. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: [email protected].
English
1120-8694
*Esophagitis/im [Immunology]
*Esophagitis/pa [Pathology]
*Immunoglobulin G/me [Metabolism]
*Plasma Cells/me [Metabolism]
Adolescent
Aged
Chronic Disease
Deglutition Disorders/et [Etiology]
Dilatation
Esophageal Stenosis/et [Etiology]
Esophagitis/di [Diagnosis]
Esophagitis/th [Therapy]
Female
Humans
Immunosuppressive Agents/tu [Therapeutic Use]
Male
Middle Aged
Retrospective Studies
Steroids/tu [Therapeutic Use]
MedStar Washington Hospital Center
Gastroenterology
Pathology
Journal Article
Immunoglobulin G4 (IgG4)-related disease is a recently coined systemic disease characterized by specific histopathologic findings of an intense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis in the presence of predominant IgG4-positive plasma cells. Although IgG4-related disease has been described in many organs, involvement of the esophagus is very rare. In this study, we describe the clinicopathologic characteristics of eight patients with IgG4-related esophagitis. We evaluated chronic esophagitis specimens with lymphoplasmacytic infiltrate obtained over the past 6 years (from January 2011 to February 2017) using a chart review, pathologic examination, and IgG4 immunohistochemical staining. The diagnoses of the specimens were either confirmed as IgG4-related esophagitis (IgG4-RE) or chronic esophagitis, not otherwise specified (CENOS), and the clinicopathologic data from each group were compared. Eight patients were diagnosed with IgG4-RE and 10 controls were identified and diagnosed with CENOS. In the IgG4-RE group, esophageal strictures were identified in three patients, two patients had postmyotomy treated achalasia, one patient had erosive esophagitis and another presented with an esophageal nodule. Only one patient had an unremarkable mucosa on endoscopy. In the CENOS group, four patients had esophageal strictures, six had erosive esophagitis, one patient had mild esophagitis. The IgG4-RE group had significantly higher numbers of IgG4-positive plasma cells (66.9 +/- 21.9 vs. 4.7 +/- 2.4 per high power field; P< 0.001) and a greater IgG4: IgG ratio 0.76 +/- 0.13 vs. 0.06 +/- 0.05; P< 0.001) when compared to CENOS patients. Two of the patients with recurrent esophageal strictures in the IgG4-RE group showed initial response to steroid therapy and are currently on immunosuppressive therapy which has significantly reduced the need for multiple esophageal dilatations. The presentation of IgG4-related esophageal disease can vary and the key to diagnosis is dependent on histopathology. These observations highlight the need for IgG4 immunohistochemical staining of esophageal biopsies especially in patients with mucosal ulceration, chronic inflammation, and plasmacytosis on biopsy. This will prevent unwarranted esophagectomies and failed medical treatment due to lack of recognition of this entity. Copyright (c) The Authors 2017. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: [email protected].
English
1120-8694
*Esophagitis/im [Immunology]
*Esophagitis/pa [Pathology]
*Immunoglobulin G/me [Metabolism]
*Plasma Cells/me [Metabolism]
Adolescent
Aged
Chronic Disease
Deglutition Disorders/et [Etiology]
Dilatation
Esophageal Stenosis/et [Etiology]
Esophagitis/di [Diagnosis]
Esophagitis/th [Therapy]
Female
Humans
Immunosuppressive Agents/tu [Therapeutic Use]
Male
Middle Aged
Retrospective Studies
Steroids/tu [Therapeutic Use]
MedStar Washington Hospital Center
Gastroenterology
Pathology
Journal Article