Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry.
Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry.
- 2019
Available online from MWHC library: 1994 - present
Copyright (c)ERS 2018. Upper airway stimulation (UAS) has been shown to reduce severity of obstructive sleep apnea (OSA). The aim of this registry was to identify predictors of UAS therapy response in an international multicenter registry. Patients who underwent UAS implantation in the US and Germany were enrolled in an observational registry. Data collected included patient characteristics, apnea-hypopnea index (AHI), Epworth Sleepiness Scale, objective adherence, adverse events, and patient satisfaction measures. Post hoc univariate and multiple logistic regression were performed to evaluate factors associated with treatment success. Between October 2016 and January 2018, 508 participants were enrolled from 14 centers. Median AHI was reduced from 34.0 to 7.0 events.h-1, median ESS reduced from 12 to 7 from baseline to final visit at 12-month post-implant. In post hoc analyses, for each 1-year increase in age, there was a 4% increase in odds of treatment success. For each 1 unit increase in BMI, there was 9% reduced odds of treatment success. In the multivariable model, age persisted in serving as statistically significant predictor of treatment success.In a large multicenter international registry, UAS is an effective treatment option with high patient satisfaction and low adverse events. Increasing age and reduced BMI are predictors of treatment response.
English
0903-1936
10.1183/13993003.01405-2018 [doi] 13993003.01405-2018 [pii]
*Electric Stimulation Therapy/is [Instrumentation]
*Implantable Neurostimulators
*Patient Satisfaction
*Product Surveillance, Postmarketing
*Sleep Apnea, Obstructive/th [Therapy]
Aged
Female
Germany
Humans
Logistic Models
Male
Middle Aged
Registries
Time Factors
Treatment Outcome
United States
MedStar Washington Hospital Center
Otolaryngology
Journal Article
Available online from MWHC library: 1994 - present
Copyright (c)ERS 2018. Upper airway stimulation (UAS) has been shown to reduce severity of obstructive sleep apnea (OSA). The aim of this registry was to identify predictors of UAS therapy response in an international multicenter registry. Patients who underwent UAS implantation in the US and Germany were enrolled in an observational registry. Data collected included patient characteristics, apnea-hypopnea index (AHI), Epworth Sleepiness Scale, objective adherence, adverse events, and patient satisfaction measures. Post hoc univariate and multiple logistic regression were performed to evaluate factors associated with treatment success. Between October 2016 and January 2018, 508 participants were enrolled from 14 centers. Median AHI was reduced from 34.0 to 7.0 events.h-1, median ESS reduced from 12 to 7 from baseline to final visit at 12-month post-implant. In post hoc analyses, for each 1-year increase in age, there was a 4% increase in odds of treatment success. For each 1 unit increase in BMI, there was 9% reduced odds of treatment success. In the multivariable model, age persisted in serving as statistically significant predictor of treatment success.In a large multicenter international registry, UAS is an effective treatment option with high patient satisfaction and low adverse events. Increasing age and reduced BMI are predictors of treatment response.
English
0903-1936
10.1183/13993003.01405-2018 [doi] 13993003.01405-2018 [pii]
*Electric Stimulation Therapy/is [Instrumentation]
*Implantable Neurostimulators
*Patient Satisfaction
*Product Surveillance, Postmarketing
*Sleep Apnea, Obstructive/th [Therapy]
Aged
Female
Germany
Humans
Logistic Models
Male
Middle Aged
Registries
Time Factors
Treatment Outcome
United States
MedStar Washington Hospital Center
Otolaryngology
Journal Article