In Vivo Formation and Tracking of pi-Peptide Nanostructures. [Review]
In Vivo Formation and Tracking of pi-Peptide Nanostructures. [Review]
- 2022
The photophysics associated with the self-assembly of pi-peptide molecules into 1-D nanostructures has been well-established, thus revealing the creation of nanoscale electronic conduits in aqueous media. Such materials have therapeutic potential in many biomedical applications. In this work, we report the in vivo deployment of these pi-peptide nanostructures in brain tissue using photothrombotic stroke as a model application. A test peptide was used for brain injections, and the nanostructures formed were visualized with electron microscopy. A new peptide bearing a low-energy fluorescence dye was prepared to facilitate direct visualization of pi-peptide localization in the brain cavity by way of fluorescence microscopy. This work demonstrates feasibility for in vivo application of pi-peptide nanostructures toward pressing biomedical challenges.
English
1944-8244
10.1021/acsami.2c04598 [doi]
IN PROCESS -- NOT YET INDEXED
MedStar Franklin Square Medical Center
Journal Article
Review
The photophysics associated with the self-assembly of pi-peptide molecules into 1-D nanostructures has been well-established, thus revealing the creation of nanoscale electronic conduits in aqueous media. Such materials have therapeutic potential in many biomedical applications. In this work, we report the in vivo deployment of these pi-peptide nanostructures in brain tissue using photothrombotic stroke as a model application. A test peptide was used for brain injections, and the nanostructures formed were visualized with electron microscopy. A new peptide bearing a low-energy fluorescence dye was prepared to facilitate direct visualization of pi-peptide localization in the brain cavity by way of fluorescence microscopy. This work demonstrates feasibility for in vivo application of pi-peptide nanostructures toward pressing biomedical challenges.
English
1944-8244
10.1021/acsami.2c04598 [doi]
IN PROCESS -- NOT YET INDEXED
MedStar Franklin Square Medical Center
Journal Article
Review