Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed.
Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed.
- 2019
Copyright (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1-3) vs. 7(4-11); P < 0.001]; >=5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01-0.83; P = 0.034).
English
2328-9503
10.1002/acn3.50834 [doi] PMC6689674 [pmc]
*Anticoagulants/tu [Therapeutic Use]
*Cerebral Hemorrhage/dt [Drug Therapy]
*Vitamin K/tu [Therapeutic Use]
Administration, Oral
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Stroke
Vitamin K/ai [Antagonists & Inhibitors]
MedStar Washington Hospital Center
Surgical Critical Care
Journal Article
Copyright (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1-3) vs. 7(4-11); P < 0.001]; >=5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01-0.83; P = 0.034).
English
2328-9503
10.1002/acn3.50834 [doi] PMC6689674 [pmc]
*Anticoagulants/tu [Therapeutic Use]
*Cerebral Hemorrhage/dt [Drug Therapy]
*Vitamin K/tu [Therapeutic Use]
Administration, Oral
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Stroke
Vitamin K/ai [Antagonists & Inhibitors]
MedStar Washington Hospital Center
Surgical Critical Care
Journal Article