Association of Serum Triglyceride Levels with Severity in Acute Pancreatitis: Results from an International, Multicenter Cohort Study.
Association of Serum Triglyceride Levels with Severity in Acute Pancreatitis: Results from an International, Multicenter Cohort Study.
- 2021
BACKGROUND: Hypertriglyceridemia (HTG) is considered within the top 5 etiologies in acute pancreatitis (AP), but the association of serum triglyceride (TG) levels with the clinical course of AP remains controversial. CONCLUSION: This large multicenter study confirms that elevated TG levels are associated with severe disease regardless of AP etiology. Copyright (c) 2021 S. Karger AG, Basel. METHODS: Patients were enrolled prospectively through APPRENTICE. High TG levels were defined based on the Endocrine Society Clinical Practice Guidelines. HTG was categorized as mild (serum TG levels 150-199 mg/dL), moderate (200-999 mg/dL), severe (1,000-1,999 mg/dL), and very severe (>=2,000 mg/dL). Severity of AP was based on the revised Atlanta classification criteria. OBJECTIVES: This study aims to examine the effect of TG levels on severity of AP. RESULTS: Early TG levels were measured in 764 subjects and found elevated in 342 (120 with mild; 176, moderate; and 46, severe/very severe HTG). Patients with increased TG levels were younger (age >=60, 16.7 vs. 30.3%), more likely to be male (66.1 vs. 51.2%), with more frequent alcohol use (62.8 vs. 50.7%), and diabetes mellitus (30.2 vs. 12.3%; all p <= 0.005). Severe AP (24.9 vs. 10.0%), ICU admission (32.5 vs. 19.7%), and mortality (5.3 vs. 1.7%; all p <= 0.005) were more frequently seen in patients with elevated TG levels. Based on multivariable analysis, elevated TG levels were independently associated with severe AP (p < 0.05).
English
0012-2823
000512682 [pii] 10.1159/000512682 [doi]
*Pancreatitis
Acute Disease
Cohort Studies
Female
Humans
Male
Retrospective Studies
Risk Factors
Severity of Illness Index
Triglycerides
MedStar Washington Hospital Center
Medicine/General Internal Medicine
News
BACKGROUND: Hypertriglyceridemia (HTG) is considered within the top 5 etiologies in acute pancreatitis (AP), but the association of serum triglyceride (TG) levels with the clinical course of AP remains controversial. CONCLUSION: This large multicenter study confirms that elevated TG levels are associated with severe disease regardless of AP etiology. Copyright (c) 2021 S. Karger AG, Basel. METHODS: Patients were enrolled prospectively through APPRENTICE. High TG levels were defined based on the Endocrine Society Clinical Practice Guidelines. HTG was categorized as mild (serum TG levels 150-199 mg/dL), moderate (200-999 mg/dL), severe (1,000-1,999 mg/dL), and very severe (>=2,000 mg/dL). Severity of AP was based on the revised Atlanta classification criteria. OBJECTIVES: This study aims to examine the effect of TG levels on severity of AP. RESULTS: Early TG levels were measured in 764 subjects and found elevated in 342 (120 with mild; 176, moderate; and 46, severe/very severe HTG). Patients with increased TG levels were younger (age >=60, 16.7 vs. 30.3%), more likely to be male (66.1 vs. 51.2%), with more frequent alcohol use (62.8 vs. 50.7%), and diabetes mellitus (30.2 vs. 12.3%; all p <= 0.005). Severe AP (24.9 vs. 10.0%), ICU admission (32.5 vs. 19.7%), and mortality (5.3 vs. 1.7%; all p <= 0.005) were more frequently seen in patients with elevated TG levels. Based on multivariable analysis, elevated TG levels were independently associated with severe AP (p < 0.05).
English
0012-2823
000512682 [pii] 10.1159/000512682 [doi]
*Pancreatitis
Acute Disease
Cohort Studies
Female
Humans
Male
Retrospective Studies
Risk Factors
Severity of Illness Index
Triglycerides
MedStar Washington Hospital Center
Medicine/General Internal Medicine
News