Clinical Outcomes and Technical Approach of Thymectomy in the Veterans Health Administration.

Clinical Outcomes and Technical Approach of Thymectomy in the Veterans Health Administration. - 2022

Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007

BACKGROUND: Thymectomy is traditionally performed via transsternal incision, but less invasive modalities have emerged, including transcervical, thoracoscopic, and robotic approaches. Despite the advantages of video-assisted thoracoscopic surgery(VATS) over thoracotomy, most thymectomies are performed via sternotomy. This study compared the utilization and 30-day post-operative outcomes of transsternal, transcervical, and VATS thymectomy in the Veterans Health Administration. CONCLUSIONS: Transsternal approach comprised most thymectomy cases amongst veterans, while VATS thymectomy utilization increased over time and was associated with favorable outcomes. 30-day outcomes after thymectomy improved over time, which may reflect a trend towards wider utilization of less invasive approaches. Future studies should examine long-term outcomes. Copyright (c) 2021. Published by Elsevier Inc. METHODS: This was a retrospective review of veterans that underwent thymectomy via the Veterans Affairs Surgical Quality Improvement Program. 30-day outcomes were compared between techniques, adjusting for confounding covariates. Temporal trends were analyzed using Spearman's rank correlation coefficient, rho(rho). RESULTS: From 2008-2019, 594 thymectomies were performed: 376(63.3%) transsternal, 113(19.0%) VATS(including robotic approaches), and 105(17.7%) transcervical cases. VATS utilization increased from 0% in 2008 to 61% of case volume in 2019. Relative to transsternal technique, VATS thymectomy was associated with decreased odds of pulmonary complications (adjusted odds ratio=0.06;p=0.028) and shorter hospital stay (2.9+/-0.4 days shorter;p<0.001). No difference in outcomes was detected between VATS and transcervical thymectomy. Post-operative complication rate decreased from 17.7% in 2008 to 5.6% in 2019 (rho=-0.101;p=0.014). Length of stay decreased from median 4 days in 2008 to 3 days in 2019 (rho=-0.093;p=0.026). In thymic cancer, VATS 5-year overall survival was non-inferior to transsternal approach(71.3% vs. 74.6%; p=0.54).


English

0003-4975

10.1016/j.athoracsur.2021.05.020 [doi] S0003-4975(21)00933-4 [pii]


*Thymectomy
*Thymus Neoplasms
Humans
Retrospective Studies
Thoracic Surgery, Video-Assisted/mt [Methods]
Thymectomy/mt [Methods]
Thymus Neoplasms/su [Surgery]
Treatment Outcome
Veterans Health


MedStar Washington Hospital Center


MedStar General Surgery Residency


Journal Article

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