Impact of Left Ventricular Outflow Tract Calcium on Hemodynamics and Outcomes in Patients After Transcatheter Aortic Valve Implantation With a Contemporary Self-Expanding Valve.
Impact of Left Ventricular Outflow Tract Calcium on Hemodynamics and Outcomes in Patients After Transcatheter Aortic Valve Implantation With a Contemporary Self-Expanding Valve.
- 2022
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
Left ventricular outflow tract (LVOT) calcium remains a challenge for transcatheter aortic valve implantation (TAVI) and is associated with an increased risk of debris embolization, permanent pacemaker requirement, and annular rupture. We report the results of the (EPROMPT) CoreValve Evolut PRO Prospective Registry, which sought to evaluate the real-world performance of the CoreValve Evolut PRO transcatheter heart valve (THV) according to computed tomography-defined extent of LVOT calcium. The prospective, investigator-initiated, multicenter registry includes patients who underwent TAVI using the CoreValve Evolut PRO/PRO+ THV system. Analyzed patients were dichotomized on the basis of the severity of their LVOT calcium at baseline (none/mild vs moderate/severe). Patients were followed with 30-day clinical assessment and echocardiography. Of the 277 patients included, 177 had computed tomography-defined none/mild LVOT calcium (63.9%), and 100 had moderate/severe LVOT calcium (36.1%). Device success was similar in both cohorts (97.7% vs 95.0%; p = 0.217). Stroke rates were numerically higher in the moderate/severe LVOT calcium cohort (in-hospital and 30 day: 1.7% vs 4.0%; p = 0.240). Patients with none/mild LVOT calcium had higher rates of permanent pacemaker implantation (in-hospital: 21.5% vs 9.0%; p = 0.008 and 30-day: 22.0% vs 12.0%; p = 0.027). At 30 days, there were numerically higher rates of >mild paravalvular leak in patients with moderate/severe LVOT calcium (1.7% vs 4.0%; p = 0.240). Thirty-day mean gradients were similar (7.5 vs 7.6 mm Hg; p = 0.782). In conclusion, patients in the EPROMPT registry receiving the contemporary self-expanding CoreValve Evolut PRO/PRO+ THV demonstrated similar short-term outcomes and hemodynamics across the entire spectrum of LVOT calcium. Copyright (c) 2021. Published by Elsevier Inc.
English
10.1016/j.amjcard.2021.12.019 [doi] S0002-9149(21)01245-5 [pii]
*Aortic Valve Stenosis
*Heart Valve Prosthesis
*Transcatheter Aortic Valve Replacement
Aortic Valve Stenosis/co [Complications]
Aortic Valve/dg [Diagnostic Imaging]
Aortic Valve/su [Surgery]
Calcium
Heart Valve Prosthesis/ae [Adverse Effects]
Hemodynamics
Humans
Prosthesis Design
Retrospective Studies
Transcatheter Aortic Valve Replacement/mt [Methods]
Treatment Outcome
MedStar Heart & Vascular Institute
MedStar Union Memorial Hospital
MedStar Washington Hospital Center
Interventional Cardiology Fellowship
Journal Article
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
Left ventricular outflow tract (LVOT) calcium remains a challenge for transcatheter aortic valve implantation (TAVI) and is associated with an increased risk of debris embolization, permanent pacemaker requirement, and annular rupture. We report the results of the (EPROMPT) CoreValve Evolut PRO Prospective Registry, which sought to evaluate the real-world performance of the CoreValve Evolut PRO transcatheter heart valve (THV) according to computed tomography-defined extent of LVOT calcium. The prospective, investigator-initiated, multicenter registry includes patients who underwent TAVI using the CoreValve Evolut PRO/PRO+ THV system. Analyzed patients were dichotomized on the basis of the severity of their LVOT calcium at baseline (none/mild vs moderate/severe). Patients were followed with 30-day clinical assessment and echocardiography. Of the 277 patients included, 177 had computed tomography-defined none/mild LVOT calcium (63.9%), and 100 had moderate/severe LVOT calcium (36.1%). Device success was similar in both cohorts (97.7% vs 95.0%; p = 0.217). Stroke rates were numerically higher in the moderate/severe LVOT calcium cohort (in-hospital and 30 day: 1.7% vs 4.0%; p = 0.240). Patients with none/mild LVOT calcium had higher rates of permanent pacemaker implantation (in-hospital: 21.5% vs 9.0%; p = 0.008 and 30-day: 22.0% vs 12.0%; p = 0.027). At 30 days, there were numerically higher rates of >mild paravalvular leak in patients with moderate/severe LVOT calcium (1.7% vs 4.0%; p = 0.240). Thirty-day mean gradients were similar (7.5 vs 7.6 mm Hg; p = 0.782). In conclusion, patients in the EPROMPT registry receiving the contemporary self-expanding CoreValve Evolut PRO/PRO+ THV demonstrated similar short-term outcomes and hemodynamics across the entire spectrum of LVOT calcium. Copyright (c) 2021. Published by Elsevier Inc.
English
10.1016/j.amjcard.2021.12.019 [doi] S0002-9149(21)01245-5 [pii]
*Aortic Valve Stenosis
*Heart Valve Prosthesis
*Transcatheter Aortic Valve Replacement
Aortic Valve Stenosis/co [Complications]
Aortic Valve/dg [Diagnostic Imaging]
Aortic Valve/su [Surgery]
Calcium
Heart Valve Prosthesis/ae [Adverse Effects]
Hemodynamics
Humans
Prosthesis Design
Retrospective Studies
Transcatheter Aortic Valve Replacement/mt [Methods]
Treatment Outcome
MedStar Heart & Vascular Institute
MedStar Union Memorial Hospital
MedStar Washington Hospital Center
Interventional Cardiology Fellowship
Journal Article