Sex differences in the clinical outcomes after left atrial appendage closure: A systematic review and meta-analysis.
Sex differences in the clinical outcomes after left atrial appendage closure: A systematic review and meta-analysis.
- 2021
Available in print through MWHC library: 2002 - present
CONCLUSION: In conclusion, women are more likely to experience worse periprocedural outcomes with longer hospital stay after LAA closure. Further efforts are needed to increase the participation of women in clinical studies and to assess these differences to properly address the discrepancy in outcomes between men and women. Copyright (c) 2021. Published by Elsevier Inc. INTRODUCTION: Left atrial appendage occlusion (LAAO) has emerged as a reasonable alternative to oral anticoagulation in a selective group of patients with atrial fibrillation (AF). While women are known have higher risk of AF-related stroke, the impact of sex differences on the clinical outcomes of LAAO has not been well studied. METHODS: We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases (from inception to October 2021) for studies evaluating the impact of sex difference on LAAO procedural outcomes. We used a random-effect model to calculate risk ratio (RR) with 95% confidence intervals (CI). In-hospital all-cause mortality and ischemic stroke were the primary endpoints. In-hospital pericardial effusion/cardiac tamponade, major bleeding, technical success, device related thrombus and hospital length of stay were secondary outcomes. OBJECTIVE: We sought to perform a meta-analysis evaluating sex differences on the outcomes of patients undergoing LAAO. RESULTS: A total of 5 studies with 54,754 patients were included, of which 22,461 (41%) were females. Female sex was associated with higher rates of in-hospital all-cause mortality (RR 2.18; 95% CI 1.46-3.26; P = 0.0001) and in-hospital ischemic stroke (RR 1.67; 95% CI 1.06-2.61; P = 0.03) when compared with males. Females had higher rates of in-hospital major bleeding (RR 1.93; 95% CI 1.40-2.67; P < 0.0001) and hospital length of stay >1 day (RR 1.38; 95% CI 1.33-1.45; P < 0.00001). There was no differences between females and males in terms of technical success and device related thrombus (RR 1.00; 95% CI 1.00-1.00; P = 1.00) and (RR 0.94, 95% CI 0.31-2.82; P = 0.91), respectively.
English
10.1016/j.carrev.2021.12.013 [doi] S1553-8389(21)00811-3 [pii]
IN PROCESS -- NOT YET INDEXED
MedStar Heart & Vascular Institute
Journal Article
Available in print through MWHC library: 2002 - present
CONCLUSION: In conclusion, women are more likely to experience worse periprocedural outcomes with longer hospital stay after LAA closure. Further efforts are needed to increase the participation of women in clinical studies and to assess these differences to properly address the discrepancy in outcomes between men and women. Copyright (c) 2021. Published by Elsevier Inc. INTRODUCTION: Left atrial appendage occlusion (LAAO) has emerged as a reasonable alternative to oral anticoagulation in a selective group of patients with atrial fibrillation (AF). While women are known have higher risk of AF-related stroke, the impact of sex differences on the clinical outcomes of LAAO has not been well studied. METHODS: We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases (from inception to October 2021) for studies evaluating the impact of sex difference on LAAO procedural outcomes. We used a random-effect model to calculate risk ratio (RR) with 95% confidence intervals (CI). In-hospital all-cause mortality and ischemic stroke were the primary endpoints. In-hospital pericardial effusion/cardiac tamponade, major bleeding, technical success, device related thrombus and hospital length of stay were secondary outcomes. OBJECTIVE: We sought to perform a meta-analysis evaluating sex differences on the outcomes of patients undergoing LAAO. RESULTS: A total of 5 studies with 54,754 patients were included, of which 22,461 (41%) were females. Female sex was associated with higher rates of in-hospital all-cause mortality (RR 2.18; 95% CI 1.46-3.26; P = 0.0001) and in-hospital ischemic stroke (RR 1.67; 95% CI 1.06-2.61; P = 0.03) when compared with males. Females had higher rates of in-hospital major bleeding (RR 1.93; 95% CI 1.40-2.67; P < 0.0001) and hospital length of stay >1 day (RR 1.38; 95% CI 1.33-1.45; P < 0.00001). There was no differences between females and males in terms of technical success and device related thrombus (RR 1.00; 95% CI 1.00-1.00; P = 1.00) and (RR 0.94, 95% CI 0.31-2.82; P = 0.91), respectively.
English
10.1016/j.carrev.2021.12.013 [doi] S1553-8389(21)00811-3 [pii]
IN PROCESS -- NOT YET INDEXED
MedStar Heart & Vascular Institute
Journal Article