Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies. (Record no. 109)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02385nam a22003377a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221213s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2072-6694 |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3390/cancers14225553 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | cancers14225553 [pii] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 36428645 |
| 245 ## - TITLE STATEMENT | |
| Title | Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies. |
| 251 ## - Source | |
| Source | Cancers. 14(22), 2022 Nov 11. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Cancers (Basel). 14(22), 2022 Nov 11. |
| 253 ## - Journal Name | |
| Journal name | Cancers |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Publication date | 2022 Nov 11 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | epublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2022-12-13 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | Pan-cancer analysis of TCGA and CPTAC (proteomics) data shows that SULF1 and SULF2 are oncogenic in a number of human malignancies and associated with poor survival outcomes. Our studies document a consistent upregulation of SULF1 and SULF2 in HNSC which is associated with poor survival outcomes. These heparan sulfate editing enzymes were considered largely functional redundant but single-cell RNAseq (scRNAseq) shows that SULF1 is secreted by cancer-associated fibroblasts in contrast to the SULF2 derived from tumor cells. Our RNAScope and patient-derived xenograft (PDX) analysis of the HNSC tissues fully confirm the stromal source of SULF1 and explain the uniform impact of this enzyme on the biology of multiple malignancies. In summary, SULF2 expression increases in multiple malignancies but less consistently than SULF1, which uniformly increases in the tumor tissues and negatively impacts survival in several types of cancer even though its expression in cancer cells is low. This paradigm is common to multiple malignancies and suggests a potential for diagnostic and therapeutic targeting of the heparan sulfatases in cancer diseases. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Vascular Surgery Integrated Residency |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Yang, Yang |
| Institution Code | MWHC |
| Program | Vascular Surgery Integrated Residency |
| Degree | MD |
| Resident year | Resident PGY 4 |
| 790 ## - Authors | |
| All authors | Ahn J, Ailles L, Benicky J, Davidson B, Edwards NJ, Goldman R, Karamboulas C, Nixon KCJ, Rozeboom AM, Yang Y |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.3390/cancers14225553">https://dx.doi.org/10.3390/cancers14225553</a> |
| Public note | https://dx.doi.org/10.3390/cancers14225553 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 12/13/2022 | 36428645 | 36428645 | 12/13/2022 | 12/13/2022 | Journal Article |