MARC details
| 000 -LEADER |
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| fixed length control field |
03019nam a22003137a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160308s20152015 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0193-1849 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
26374766 |
| 245 ## - TITLE STATEMENT |
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| Title |
Vasodilator responses and endothelin-dependent vasoconstriction in metabolically healthy obesity and the metabolic syndrome. |
| 251 ## - Source |
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| Source |
American Journal of Physiology - Endocrinology & Metabolism. 309(9):E787-92, 2015 Nov 1. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Am J Physiol Endocrinol Metab. 309(9):E787-92, 2015 Nov 1. |
| 253 ## - Journal Name |
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| Journal name |
American journal of physiology. Endocrinology and metabolism |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2015 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2016 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2016-05-24 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1997 - present (after 1 year) |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Patients with metabolically healthy obesity (MHO) do not present the cluster of metabolic abnormalities that define the metabolic syndrome (MetS). Whether MHO is associated with lower impairment of vasoreactivity than the MetS is unknown. For this purpose, forearm blood flow (FBF) responses were measured by strain-gauge plethysmography during the intra-arterial infusion of acetylcholine (ACh), sodium nitroprusside (SNP), and/or the selective endothelin type A (ETA) receptor blocker BQ-123 in 119 obese individuals with MHO (n = 34) or with the MetS (n = 85) and in healthy lean controls (n = 56). ACh and SNP caused a significant vasodilation in both obese and lean participants (all P < 0.001). However, the response to both agents was significantly lower in the obese than in the control group (both P < 0.001). Among the obese participants, the reactivity to ACh was higher in MHO than in MetS patients, whereas the responsiveness to SNP was equally impaired in both groups (P = 0.45). Infusion of BQ-123 significantly increased FBF in obese patients (P < 0001), but not in the lean participants; hence, FBF following ETA receptor blockade was higher in both obese groups than in controls (both P < 0.001). FBF response to BQ-123 was significantly higher in patients with the MetS than in those with MHO (P = 0.007). In conclusion, patients with MHO have abnormal vascular reactivity, although their endothelial dysfunction is less pronounced than in patients with the MetS. These findings indicate that obesity is associated with vascular damage independent of those metabolic abnormalities underlying the MetS. Copyright © 2015 the American Physiological Society. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Randomized Controlled Trial |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Research Support, Non-U.S. Gov't |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Campia, Umberto |
| 790 ## - Authors |
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| All authors |
Campia U, Cardillo C, Di Daniele N, Iantorno M, Mores N, Rovella V, Schinzari F, Tesauro M |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1152/ajpendo.00278.2015">http://dx.doi.org/10.1152/ajpendo.00278.2015</a> |
| Public note |
http://dx.doi.org/10.1152/ajpendo.00278.2015 |
| 858 ## - ORCID |
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| ORCID text |
Campia, Umberto; |
| Orcid |
<a href="http://orcid.org/0000-0002-7894-3565">http://orcid.org/0000-0002-7894-3565</a> |
| Name |
http://orcid.org/0000-0002-7894-3565 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
