MARC details
| 000 -LEADER |
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| fixed length control field |
03213nam a22004337a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190314s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2472-1972 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1210/js.2018-00320 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
js_201800320 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC6364625 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30746503 |
| 245 ## - TITLE STATEMENT |
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| Title |
Hyponatremia Is Associated With Increased Osteoporosis and Bone Fractures in Patients With Diabetes With Matched Glycemic Control. |
| 251 ## - Source |
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| Source |
Journal of the Endocrine Society. 3(2):411-426, 2019 Feb 01. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J. endocr. soc.. 3(2):411-426, 2019 Feb 01. |
| 253 ## - Journal Name |
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| Journal name |
Journal of the Endocrine Society |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-03-14 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Conclusions: Our analyses support the hypothesis that hyponatremia is an additional risk factor for osteoporosis and fragility fracture among patients with diabetes mellitus. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Context: Patients with diabetes mellitus are at increased risk for bone fragility fracture secondary to multiple mechanisms. Hyperglycemia can induce true dilutional hyponatremia. Hyponatremia is associated with gait instability, osteoporosis, and increased falls and bone fractures, and studies suggest that compromised bone quality with hyponatremia may be independent of plasma osmolality. We performed a case-control study of patients with diabetes mellitus matched by median glycated hemoglobin (HbA1c) to assess whether hyponatremia was associated with increased risk of osteoporosis and/or fragility fracture. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Design: Osteoporosis (n = 823) and fragility fracture (n = 840) cases from the MedStar Health database were matched on age of first HbA1c >=6.5%, sex, race, median HbA1c over an interval from first HbA1c >=6.5% to the end of the encounter window, diabetic encounter window length, and type 1 vs type 2 diabetes mellitus with controls without osteoporosis (n = 823) and without fragility fractures (n = 840), respectively. Clinical variables, including coefficient of glucose variation and hyponatremia (defined as serum [Na<sup>+</sup>] <135 mmol/dL within 30 days of the end of the diabetic window), were included in a multivariate analysis. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Results: Multivariate conditional logistic regression models demonstrated that hyponatremia within 30 days of the outcome measure was independently associated with osteoporosis and fragility fractures (osteoporosis OR 3.09; 95% CI, 1.37 to 6.98; fracture OR, 6.41; 95% CI, 2.44 to 16.82). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/General Internal Medicine |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Fernandez, Stephen J |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Mete, Mihriye |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shara, Nawar M |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Usala, Rachel L |
| 790 ## - Authors |
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| All authors |
Fernandez SJ, Mete M, Shara NM, Usala RL, Verbalis JG |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1210/js.2018-00320">https://dx.doi.org/10.1210/js.2018-00320</a> |
| Public note |
https://dx.doi.org/10.1210/js.2018-00320 |
| 858 ## - ORCID |
|---|
| ORCID text |
Usala, Rachel L |
| Orcid |
<a href="https://orcid.org/0000-0002-3480-5996">https://orcid.org/0000-0002-3480-5996</a> |
| Name |
https://orcid.org/0000-0002-3480-5996 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
