Discovery and refinement of loci associated with lipid levels. (Record no. 1132)

MARC details
000 -LEADER
fixed length control field 05727nam a22004817a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130224s20132013 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1061-4036
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 24097068
245 ## - TITLE STATEMENT
Title Discovery and refinement of loci associated with lipid levels.
251 ## - Source
Source Nature Genetics. 45(11):1274-83, 2013 Nov.
252 ## - Abbreviated Source
Abbreviated source Nat Genet. 45(11):1274-83, 2013 Nov.
253 ## - Journal Name
Journal name Nature genetics
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2013
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2014
266 ## - Date added to catalog
Date added to catalog 2014-02-24
520 ## - SUMMARY, ETC.
Abstract Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Coronary Artery Disease/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Coronary Artery Disease/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Lipids/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Lipids/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element African Continental Ancestry Group/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Asian Continental Ancestry Group/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cholesterol, HDL/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cholesterol, HDL/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cholesterol, LDL/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cholesterol, LDL/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element European Continental Ancestry Group/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Predisposition to Disease
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genome-Wide Association Study
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genotype
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Triglycerides/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Triglycerides/ge [Genetics]
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Burnett, Mary Susan
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Epstein, Stephen E
790 ## - Authors
All authors Abecasis GR, Absher D, Adair LS, Arveiler D, Asiki G, Assimes TL, Bandinelli S, Barroso I, Beckmann JS, Been LF, Bennett F, Bochud M, Boehm BO, Boehnke M, Boerwinkle E, Bolton JL, Bonnycastle LL, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Bragg-Gresham JL, Brambilla P, Buchkovich ML, Burnett MS, Burnier M, Campbell H, Cesana G, Chakravarti A, Chambers JC, Chang HY, Chasman DI, Chen J, Chen YD, Collins FS, Cooper RS, Cupples LA, Danesh J, de Faire U, Dedoussis G, Deloukas P, Demirkan A, Den Hertog HM, Dimitriou M, Do R, Doney AS, Donnelly LA, Doring A, Ehret GB, Elliott P, Epstein SE, Esko T, Eyjolfsson GI, Feitosa MF, Feranil AB, Ferreira T, Ferrieres J, Ferrucci L, Fischer K, Fontanillas P, Franks PW, Fraser RM, Freimer NB, Freitag DF, Ganna A, Gieger C, Gigante B, Global Lipids Genetics Consortium, Goodarzi MO, Grallert H, Gravito ML, Groop LC, Groves CJ, Gudnason V, Gurdasani D, Gustafsson S, Gyllensten U, Hallmans G, Hamsten A, Harris TB, Hartikainen AL, Hayward C, Heikkila K, Hernandez D, Hicks AA, Hingorani A, Hirschhorn JN, Hofman A, Holm H, Hovingh GK, Hsiung CA, Humphries SE, Hung YJ, Hunt SC, Hveem K, Hypponen E, Illig T, Ingelsson E, Iribarren C, Isaacs A, Jackson AU, Jarvelin MR, Johansson A, Johnson T, Jones MR, Jula A, Kaakinen M, Kahonen M, Kaleebu P, Kanoni S, Kaprio J, Kastelein JJ, Kathiresan S, Kesaniemi A, Kettunen J, Khaw KT, Kim E, Kivimaki M, Kleber ME, Klopp N, Komulainen P, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kumari M, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Langenberg C, Lehtimaki T, Li X, Lin SY, Lind L, Lindgren CM, Lindstrom J, Loos RJ, Luan J, Lyytikainen LP, Mach F, Magnusson PK, Mangino M, Martin NG, Marz W, McArdle WL, McCarthy MI, McKenzie CA, Meisinger C, Meneton P, Metspalu A, Mihailov E, Mitchell BD, Mohlke KL, Moilanen L, Montasser ME, Mora S, Morris AD, Muller G, Muller-Nurasyid M, Munroe PB, Nagaraja R, Narisu N, Nieminen TV, Njolstad I, Nolte IM, Nsubuga RN, O'Connell JR, Olafsson I, Ong KK, Ordovas JM, Palmer CD, Palmer CN, Palotie A, Papamarkou T, Pedersen NL, Peloso GM, Perola M, Petersen AK, Pomilla C, Pouta A, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rader DJ, Rauramaa R, Reilly MP, Rich SS, Ridker PM, Ripatti S, Rivadeneira F, Rotter JI, Rudan I, Ruokonen A, Saleheen D, Salomaa V, Samani N, Sandhu MS, Sanghera DK, Sanna S, Saramies J, Saxena R, Scharnagl H, Schmidt EM, Schwarz PE, Seeley J, Sengupta S, Service SK, Shah S, Sheu WH, Shuldiner AR, Shungin D, Sidore C, Siegbahn A, Silander K, Song C, Spector TD, Stancakova A, Stefansson K, Stirrups K, Strachan DP, Strawbridge RJ, Surakka I, Swift AJ, Tanaka T, Tayo BO, Teslovich TM, Thorleifsson G, Thorsteinsdottir U, Tiret L, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Van den Herik EG, van Duijn CM, van Pelt LJ, Vedantam S, Voight BF, Volcik KA, Vollenweider P, Wainwright N, Waite LL, Wallentin L, Wareham NJ, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Willer CJ, Wilsgaard T, Wilson JF, Wolffenbuttel BH, Wong A, Wu Y, Young EH, Zhang W, Zhao JH
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="http://dx.doi.org/10.1038/ng.2797">http://dx.doi.org/10.1038/ng.2797</a>
Public note http://dx.doi.org/10.1038/ng.2797
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
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