MARC details
| 000 -LEADER |
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| fixed length control field |
03435nam a22004577a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160115s20092009 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1546-1718 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
19820697 |
| 245 ## - TITLE STATEMENT |
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| Title |
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. |
| 251 ## - Source |
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| Source |
Nature Genetics. 41(11):1182-90, 2009 Nov. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Nat Genet. 41(11):1182-90, 2009 Nov. |
| 253 ## - Journal Name |
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| Journal name |
Nature genetics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2009 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2009 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2016-01-15 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Blood Cells |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Genome-Wide Association Study |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Genome, Human |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Blood Cell Count |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Blood Cells/cy [Cytology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Chromosomes, Human, Pair 12 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Coronary Artery Disease/ge [Genetics] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Genetic Markers |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Polymorphism, Single Nucleotide |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Selection, Genetic |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Meta-Analysis |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Research Support, N.I.H., Extramural |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Research Support, Non-U.S. Gov't |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Burnett, Mary Susan |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Devaney, Joseph M |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Epstein, Stephen E |
| 790 ## - Authors |
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| All authors |
Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Burns P, Chen L, Deloukas P, Devaney J, Doring A, Elosua R, Epstein SE, Erber W, Erdmann J, Falchi M, Garner SF, Ghori MJ, Gieger C, Goodall AH, Greinacher A, Gwilliam R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, Kathiresan S, Knouff CW, Konig IR, Kuhnel B, Laskowski RA, Li M, Mangino M, McPherson R, Meisinger C, Melander O, Menzel S, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Ouwehand WH, Peltonen L, Perola M, Potter SC, Prokisch H, Rader DJ, Reilly MP, Rendon A, Rice CM, Roberts R, Salo P, Salomaa V, Samani NJ, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Soranzo N, Spector TD, Stark K, Stephens J, Stewart AF, Surakka I, Teumer A, Thein SL, Thompson JR, Tyler-Smith C, Van Heel DA, Voight BF, Volker U, Volzke H, Watkins NA, Wells GA, Wichmann HE, Willenborg C, Wright B, Xue Y |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1038/ng.467">http://dx.doi.org/10.1038/ng.467</a> |
| Public note |
http://dx.doi.org/10.1038/ng.467 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
