Two-year outcomes after transcatheter or surgical aortic-valve replacement. (Record no. 12001)

MARC details
000 -LEADER
fixed length control field 04945nam a22006977a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130916s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0028-4793
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 22443479
245 ## - TITLE STATEMENT
Title Two-year outcomes after transcatheter or surgical aortic-valve replacement.
251 ## - Source
Source New England Journal of Medicine. 366(18):1686-95, 2012 May 3.
252 ## - Abbreviated Source
Abbreviated source N Engl J Med. 366(18):1686-95, 2012 May 3.
253 ## - Journal Name
Journal name The New England journal of medicine
266 ## - Date added to catalog
Date added to catalog 2013-09-17
501 ## - WITH NOTE
Local holdings Available online from MWHC library: 1993 - present, Available in print through MWHC library: 1980 - present
520 ## - SUMMARY, ETC.
Abstract BACKGROUND: The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that among high-risk patients with aortic stenosis, the 1-year survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical replacement. However, longer-term follow-up is necessary to determine whether TAVR has prolonged benefits.
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: A 2-year follow-up of patients in the PARTNER trial supports TAVR as an alternative to surgery in high-risk patients. The two treatments were similar with respect to mortality, reduction in symptoms, and improved valve hemodynamics, but paravalvular regurgitation was more frequent after TAVR and was associated with increased late mortality. (Funded by Edwards Lifesciences; ClinicalTrials.gov number, NCT00530894.).
520 ## - SUMMARY, ETC.
Abstract METHODS: At 25 centers, we randomly assigned 699 high-risk patients with severe aortic stenosis to undergo either surgical aortic-valve replacement or TAVR. All patients were followed for at least 2 years, with assessment of clinical outcomes and echocardiographic evaluation.
520 ## - SUMMARY, ETC.
Abstract RESULTS: The rates of death from any cause were similar in the TAVR and surgery groups (hazard ratio with TAVR, 0.90; 95% confidence interval [CI], 0.71 to 1.15; P=0.41) and at 2 years (Kaplan-Meier analysis) were 33.9% in the TAVR group and 35.0% in the surgery group (P=0.78). The frequency of all strokes during follow-up did not differ significantly between the two groups (hazard ratio, 1.22; 95% CI, 0.67 to 2.23; P=0.52). At 30 days, strokes were more frequent with TAVR than with surgical replacement (4.6% vs. 2.4%, P=0.12); subsequently, there were 8 additional strokes in the TAVR group and 12 in the surgery group. Improvement in valve areas was similar with TAVR and surgical replacement and was maintained for 2 years. Paravalvular regurgitation was more frequent after TAVR (P<0.001), and even mild paravalvular regurgitation was associated with increased late mortality (P<0.001).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Aortic Valve Stenosis/su [Surgery]
9 (RLIN) 37
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Aortic Valve/su [Surgery]
9 (RLIN) 413
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Cardiac Catheterization
9 (RLIN) 32
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Heart Valve Prosthesis Implantation/mt [Methods]
9 (RLIN) 34
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Anticoagulants/ae [Adverse Effects]
9 (RLIN) 411
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Anticoagulants/tu [Therapeutic Use]
9 (RLIN) 412
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Insufficiency/cl [Classification]
9 (RLIN) 415
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Insufficiency/et [Etiology]
9 (RLIN) 416
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/co [Complications]
9 (RLIN) 417
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/mo [Mortality]
9 (RLIN) 418
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/th [Therapy]
9 (RLIN) 31
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve/us [Ultrasonography]
9 (RLIN) 414
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cardiac Catheterization/ae [Adverse Effects]
9 (RLIN) 38
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
9 (RLIN) 7
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Follow-Up Studies
9 (RLIN) 419
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Heart Valve Prosthesis Implantation/ae [Adverse Effects]
9 (RLIN) 41
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Heart Valve Prosthesis
9 (RLIN) 420
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hemorrhage/et [Etiology]
9 (RLIN) 421
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Heparin/ae [Adverse Effects]
9 (RLIN) 422
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Heparin/tu [Therapeutic Use]
9 (RLIN) 423
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
9 (RLIN) 11
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Kaplan-Meier Estimate
9 (RLIN) 424
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
9 (RLIN) 14
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Platelet Aggregation Inhibitors/ae [Adverse Effects]
9 (RLIN) 425
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Platelet Aggregation Inhibitors/tu [Therapeutic Use]
9 (RLIN) 426
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Postoperative Complications
9 (RLIN) 307
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Prosthesis Failure
9 (RLIN) 427
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Stroke/et [Etiology]
9 (RLIN) 428
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Survival Rate
9 (RLIN) 429
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Treatment Outcome
9 (RLIN) 18
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Heart & Vascular Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Comparative Study
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
657 ## - INDEX TERM--FUNCTION
Medline publication type Multicenter Study
657 ## - INDEX TERM--FUNCTION
Medline publication type Randomized Controlled Trial
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, Non-U.S. Gov't
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Pichard, Augusto D
9 (RLIN) 27
790 ## - Authors
All authors Akin JJ, Anderson WN, Dewey TM, Douglas PS, Fischbein M, Fontana GP, Greason KL, Hahn RT, Kodali SK, Leon MB, Lim S, Makkar RR, Malaisrie SC, PARTNER Trial Investigators, Pichard AD, Smith CR, Svensson LG, Szeto WY, Teirstein PS, Thourani VH, Wang D, Webb JG, Whisenant B, Williams MR, Zajarias A
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="http://dx.doi.org/10.1056/NEJMoa1200384">http://dx.doi.org/10.1056/NEJMoa1200384</a>
Public note http://dx.doi.org/10.1056/NEJMoa1200384
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Journal article
Source of classification or shelving scheme Other/Generic Classification Scheme
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 09/17/2013   22443479 09/17/2013 09/17/2013 Journal Article

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