MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04513nam a22004817a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
130917s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
0098-7484 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
22797450 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Lipid-related markers and cardiovascular disease prediction. |
| 251 ## - Source |
|---|
| Source |
JAMA. 307(23):2499-506, 2012 Jun 20. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
JAMA. 307(23):2499-506, 2012 Jun 20. |
| 253 ## - Journal Name |
|---|
| Journal name |
JAMA : the journal of the American Medical Association |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2013-09-17 |
| 501 ## - WITH NOTE |
|---|
| Local holdings |
Available online from MWHC library: 1998 - present, Available in print through MWHC library: 1999 - present |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
CONCLUSION: In a study of individuals without known CVD, the addition of information on the combination of apolipoprotein B and A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 mass to risk scores containing total cholesterol and HDL-C led to slight improvement in CVD prediction. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
CONTEXT: The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
DESIGN, SETTING, AND PARTICIPANTS: Individual records were available for 165,544 participants without baseline CVD in 37 prospective cohorts (calendar years of recruitment: 1968-2007) with up to 15,126 incident fatal or nonfatal CVD outcomes (10,132 CHD and 4994 stroke outcomes) during a median follow-up of 10.4 years (interquartile range, 7.6-14 years). |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
MAIN OUTCOME MEASURES: Discrimination of CVD outcomes and reclassification of participants across predicted 10-year risk categories of low (<10%), intermediate (10%-<20%), and high (>=20%) risk. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: The addition of information on various lipid-related markers to total cholesterol, HDL-C, and other conventional risk factors yielded improvement in the model's discrimination: C-index change, 0.0006 (95% CI, 0.0002-0.0009) for the combination of apolipoprotein B and A-I; 0.0016 (95% CI, 0.0009-0.0023) for lipoprotein(a); and 0.0018 (95% CI, 0.0010-0.0026) for lipoprotein-associated phospholipase A2 mass. Net reclassification improvements were less than 1% with the addition of each of these markers to risk scores containing conventional risk factors. We estimated that for 100,000 adults aged 40 years or older, 15,436 would be initially classified at intermediate risk using conventional risk factors alone. Additional testing with a combination of apolipoprotein B and A-I would reclassify 1.1%; lipoprotein(a), 4.1%; and lipoprotein-associated phospholipase A2 mass, 2.7% of people to a 20% or higher predicted CVD risk category and, therefore, in need of statin treatment under Adult Treatment Panel III guidelines. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Biological Markers/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Cardiovascular Diseases/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Cardiovascular Diseases/ep [Epidemiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Lipoproteins/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cholesterol, HDL/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cohort Studies |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Male |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Middle Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Risk Assessment |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Medicine/General Internal Medicine |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Research Support, Non-U.S. Gov't |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Howard, William J |
| 790 ## - Authors |
|---|
| All authors |
Assmann G, Ballantyne CM, Barrett-Connor E, Boekholdt SM, Brunner E, Butterworth AS, Casiglia E, Caslake M, Clarke R, Cooper JA, D'Agostino RB Sr, Dagenais GR, Danesh J, Di Angelantonio E, Ducimetiere P, Dullaart RP, Emerging Risk Factors Collaboration, Ford I, Fowkes FG, Gallacher J, Gao P, Gillum RF, Gomez-de-la-Camara A, Gudnason V, Hofman A, Howard WJ, Jukema JW, Kaptoge S, Kauhanen J, Khaw KT, Kiechl S, Koenig W, Kromhout D, Nagel D, Nordestgaard BG, Onat A, Packard C, Pennells L, Psaty BM, Ridker PM, Rosengren A, Saleheen D, Salomaa V, Salonen JT, Sandhu M, Sarwar N, Sattar N, Simons LA, Sundstrom J, Sutherland SE, Thompson A, Thompson SG, Tipping RW, Wareham NJ, Wood AM, Wormser D |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="http://dx.doi.org/10.1001/jama.2012.6571">http://dx.doi.org/10.1001/jama.2012.6571</a> |
| Public note |
http://dx.doi.org/10.1001/jama.2012.6571 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Journal article |
