MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03771nam a22003017a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160113s20152015 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
1079-5642 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
25977570 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. |
| 251 ## - Source |
|---|
| Source |
Arteriosclerosis, Thrombosis & Vascular Biology. 35(7):1712-22, 2015 Jul. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
Arterioscler Thromb Vasc Biol. 35(7):1712-22, 2015 Jul. |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2016-01-13 |
| 501 ## - WITH NOTE |
|---|
| Local holdings |
Available online from MWHC library: 1995 - present |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
APPROACHES AND RESULTS: Using pathways (gene sets) from Reactome, we carried out a 2-stage gene set enrichment analysis strategy. From a meta-analyzed discovery cohort of 7 CAD genome-wide association study data sets (9889 cases/11089 controls), nominally significant gene sets were tested for replication in a meta-analysis of 9 additional studies (15502 cases/55730 controls) from the Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) Consortium. A total of 32 of 639 Reactome pathways tested showed convincing association with CAD (replication P<0.05). These pathways resided in 9 of 21 core biological processes represented in Reactome, and included pathways relevant to extracellular matrix (ECM) integrity, innate immunity, axon guidance, and signaling by PDRF (platelet-derived growth factor), NOTCH, and the transforming growth factor-beta/SMAD receptor complex. Many of these pathways had strengths of association comparable to those observed in lipid transport pathways. Network analysis of unique genes within the replicated pathways further revealed several interconnected functional and topologically interacting modules representing novel associations (eg, semaphoring-regulated axonal guidance pathway) besides confirming known processes (lipid metabolism). The connectivity in the observed networks was statistically significant compared with random networks (P<0.001). Network centrality analysis (degree and betweenness) further identified genes (eg, NCAM1, FYN, FURIN, etc) likely to play critical roles in the maintenance and functioning of several of the replicated pathways. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
CONCLUSIONS: These findings provide novel insights into how genetic variation, interpreted in the context of biological processes and functional interactions among genes, may help define the genetic architecture of CAD.Copyright � 2015 American Heart Association, Inc. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
OBJECTIVE: Genome-wide association studies have identified multiple genetic variants affecting the risk of coronary artery disease (CAD). However, individually these explain only a small fraction of the heritability of CAD and for most, the causal biological mechanisms remain unclear. We sought to obtain further insights into potential causal processes of CAD by integrating large-scale GWA data with expertly curated databases of core human pathways and functional networks. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Coronary Artery Disease/ge [Genetics] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Genome-Wide Association Study |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Coronary Artery Disease/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Humans |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Health Research Institute |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Epstein, Stephen E |
| 790 ## - Authors |
|---|
| All authors |
Assimes TL, Blankenberg S, Epstein SE, Erdmann J, Ghosh S, Granger CB, Hazen SL, Kathiresan S, Laaksonen R, Makinen VP, Marz W, McPherson R, Nelson CP, Nikpay M, O'Donnell C, Quertermous T, Reilly MP, Samani NJ, Schunkert H, Segre AV, Shah SH, Stewart AF, Vivar J, Willenborg C, Yang X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="http://dx.doi.org/10.1161/ATVBAHA.115.305513">http://dx.doi.org/10.1161/ATVBAHA.115.305513</a> |
| Public note |
http://dx.doi.org/10.1161/ATVBAHA.115.305513 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Journal article |
