MARC details
000 -LEADER |
fixed length control field |
05829nam a22006137a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190521s20192019 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0026-4075 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1093/milmed/usy397 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
5418659 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
30901410 |
245 ## - TITLE STATEMENT |
Title |
Utilizing Plasma Composition Data to Help Determine Procoagulant Dynamics in Patients with Thermal Injury: A Computational Assessment. |
251 ## - Source |
Source |
Military Medicine. 184(Suppl 1):392-399, 2019 03 01. |
252 ## - Abbreviated Source |
Abbreviated source |
Mil Med. 184(Suppl 1):392-399, 2019 03 01. |
253 ## - Journal Name |
Journal name |
Military medicine |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2019 |
Manufacturer |
FY2019 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
266 ## - Date added to catalog |
Date added to catalog |
2019-05-21 |
501 ## - WITH NOTE |
Local holdings |
Available in print through MWHC library: 1999 - 2005 |
520 ## - SUMMARY, ETC. |
Abstract |
CONCLUSIONS: Thrombin and FXa generation are increased in burn patients at admission compared to mean physiological simulations. Over the first 48 hours, burn survivors became more procoagulant while non-survivors became less procoagulant. Differences between survivors and non-survivors appear to be present in the underlying dynamics that contribute to FXa dynamics. Understanding how the individual specific balance of procoagulant and anticoagulant proteins contributes to thrombin and FXa generation could ultimately guide therapy and potentially reduce burn injury-related morbidity and mortality. |
520 ## - SUMMARY, ETC. |
Abstract |
Copyright (c) Association of Military Surgeons of the United States 2019. All rights reserved. For permissions, please e-mail: [email protected]. |
520 ## - SUMMARY, ETC. |
Abstract |
INTRODUCTION: The development of methods that generate individualized assessments of the procoagulant potential of burn patients could improve their treatment. Beyond its role as an essential intermediate in the formation of thrombin, factor (F)Xa has systemic effects as an agonist to inflammatory processes. In this study, we use a computational model to study the FXa dynamics underlying tissue factor-initiated thrombin generation in a small cohort of burn patients. |
520 ## - SUMMARY, ETC. |
Abstract |
MATERIALS AND METHODS: Plasma samples were collected upon admission (Hour 0) from nine subjects (five non-survivors) with major burn injuries and then at 48 hours. Coagulation factor concentrations (II, V, VII, VIII, IX, X, TFPI, antithrombin (AT), protein C (PC)) were measured and used in a computational model to generate time course profiles for thrombin (IIa), FXa, extrinsic tenase, intrinsic tenase and prothrombinase complexes upon a 5 pM tissue factor stimulus in the presence of 1 nM thrombomodulin. Parameters were extracted from the thrombin and FXa profiles (including max rate (MaxRIIa and MaxRFXa) and peak level (MaxLIIa and MaxLFXa)). Procoagulant potential was also evaluated by determining the concentration of the complexes at select times. Parameter values were compared between survivors and non-survivors in the burn cohort and between the burn cohort and a simulation based on the mean physiological (100%) concentration for all factor levels. |
520 ## - SUMMARY, ETC. |
Abstract |
RESULTS: Burn patients differed at Hour 0 (p < 0.05) from 100% mean physiological levels for all coagulation factor levels except FV and FVII. The concentration of FX, FII, TFPI, AT and PC was lower; FIX and FVIII were increased. The composition differences resulted in all nine burn patients at Hour 0 displaying a procoagulant phenotype relative to 100% mean physiological simulation (MaxLIIa (306 +/- 90 nM vs. 52 nM), MaxRIIa (2.9 +/- 1.1 nM/s vs. 0.3 nM/s), respectively p < 0.001); MaxRFXa and MaxLFXa were also an order of magnitude greater than 100% mean physiological simulation (p < 0.001). When grouped by survival status and compared at the time of admission, non-survivors had lower PC levels (56 +/- 18% vs. 82 +/- 9%, p < 0.05), and faster MaxRFXa (29 +/- 6 pM/s vs. 18 +/- 6 pM/s, p < 0.05) than those that survived; similar trends were observed for all other procoagulant parameters. At 48 hours when comparing non-survivors to survivors, TFPI levels were higher (108 +/- 18% vs. 59 +/- 18%, p < 0.05), and MaxRIIa (1.5 +/- 1.4 nM/s vs. 3.6 +/- 0.7 nM/s, p < 0.05) and MaxRFXa (13 +/- 12 pM/s vs. 35 +/- 4 pM/s, p < 0.05) were lower; similar trends were observed with all other procoagulant parameters. Overall, between admission and 48 hours, procoagulant potential, as represented by MaxR and MaxL parameters for thrombin and FXa, in non-survivors decreased while in survivors they increased (p < 0.05). In patients that survived, there was a positive correlation between FX levels and MaxLFXa (r = 0.96) and reversed in mortality (r= -0.91). |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Burns/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Burns/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Coagulants/an [Analysis] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Analysis of Variance |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Area Under Curve |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Blood Coagulation Tests/mt [Methods] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Burns/en [Enzymology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Coagulants/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Cohort Studies |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Factor Xa/an [Analysis] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Pilot Projects |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
ROC Curve |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Thrombin/an [Analysis] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Time Factors |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Health Research Institute |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Washington Hospital Center |
656 ## - INDEX TERM--OCCUPATION |
Department |
Firefighters' Burn and Surgical Research Laboratory |
656 ## - INDEX TERM--OCCUPATION |
Department |
Surgery/Burn Services |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Research Support, U.S. Gov't, Non-P.H.S. |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
McLawhorn, Melissa M |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Moffatt, Lauren T |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Shupp, Jeffrey W |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Tejiram, Shawn |
790 ## - Authors |
All authors |
Bravo MC, Brummel-Ziedins KE, Jett-Tilton M, McLawhorn MM, Moffatt LT, Orfeo T, Pusateri AE, Shupp JW, Tejiram S |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1093/milmed/usy397">https://dx.doi.org/10.1093/milmed/usy397</a> |
Public note |
https://dx.doi.org/10.1093/milmed/usy397 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Journal article |