Evaluation of the Recommended 30 cc/kg Fluid Dose for Patients With Septic Shock and Hypoperfusion With Lactate Greater Than 4 mmol/L. (Record no. 13075)
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| fixed length control field | 03648nam a22004577a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230815s20232023 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2639-8028 |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1097/CCE.0000000000000932 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | PMC10348724 [pmc] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 37457917 |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of the Recommended 30 cc/kg Fluid Dose for Patients With Septic Shock and Hypoperfusion With Lactate Greater Than 4 mmol/L. |
| 251 ## - Source | |
| Source | Critical Care Explorations. 5(7):e0932, 2023 Jul. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Crit. care explor.. 5(7):e0932, 2023 Jul. |
| 253 ## - Journal Name | |
| Journal name | Critical care explorations |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2024 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Publication date | 2023 Jul |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | epublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Medline status | PubMed-not-MEDLINE |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2023-08-15 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | CONCLUSIONS: In patients with sepsis and lactate value greater than 4 mmol/L, high or low fluid doses were not associated with better lactate clearance or patient outcomes. Greater than 50 cc/kg IBW dose of fluids within 3 hours is associated with higher mortality. Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | DESIGN: Multicenter retrospective observational study. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | INTERVENTIONS: None. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | MEASUREMENTS AND MAIN RESULTS: We stratified patients into five groups based on the dose of fluid administered within 3 hours after sepsis identification. The groupings were less than 15 cc/kg IBW, 15.1-25 cc/kg IBW, 25.1-35 cc/kg IBW, 35.1-50 cc/kg IBW, and greater than 50 cc/kg IBW. We used the group that received a fluid dose of 25.1-35 cc/kg IBW, as a reference group. The mean age was 66 years, and 56% were male. Three hundred seventy-one (25%) received less than 15 cc/kg of IBW of crystalloid fluid, 278 (17%) received 15-25 cc/kg of IBW, 316 (21%) received 25.1-35 cc/kg of IBW, 319 (21%) received 35.1-50 cc/kg of IBW, and 207 (14%) received greater than 50 cc/kg of IBW. After multilinear regression, there was no significant difference in lactate normalization between the reference group and any of the other fluid groups. We also found no statistically significant difference in the observed/expected cost, or observed/expected length of stay, between the reference group and any of the other fluid groups. Mortality was higher among patients who received greater than 50 cc/kg IBW when compared to the recommended dose. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | PATIENTS: Patients with sepsis, initial lactate value greater than 4 mmol/L, and received appropriate antibiotics within 3 hours. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | SETTING: Eight-hospital urban healthcare system in Northeastern United States. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | The Surviving Sepsis Campaign Guidelines recommend fluid administration of 30 cc/kg ideal body weight (IBW) for patients with sepsis and lactate greater than 4 mmol/L within 3 hours of identification. In this study, we explore the impact of fluid dose on lactate normalization, treatment cost, length of stay, and mortality in patients with lactate greater than 4. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Indexing | Automated |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Internal Medicine Residency |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Surgery/Surgical Critical Care |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Piccolo Serafim, Laura |
| Institution Code | MWHC |
| Program | Internal Medicine Residency |
| Degree | MD |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Pratt, Alexandra |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Yohannes, Seife |
| Institution Code | MWHC |
| 790 ## - Authors | |
| All authors | Cabrera M, Chin MK, O'Connor T, Pratt A, Serafim LP, Slavinsky V, Yohannes S |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.1097/CCE.0000000000000932">https://dx.doi.org/10.1097/CCE.0000000000000932</a> |
| Public note | https://dx.doi.org/10.1097/CCE.0000000000000932 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
No items available.