Longitudinal Lipidomic Profile of Hypertension in American Indians: Findings From the Strong Heart Family Study. (Record no. 13089)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03580nam a22004937a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230815s20232023 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0194-911X |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1161/HYPERTENSIONAHA.123.21144 [doi] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 37334699 |
| 245 ## - TITLE STATEMENT | |
| Title | Longitudinal Lipidomic Profile of Hypertension in American Indians: Findings From the Strong Heart Family Study. |
| 251 ## - Source | |
| Source | Hypertension. 80(8):1771-1783, 2023 08. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Hypertension. 80(8):1771-1783, 2023 08. |
| 253 ## - Journal Name | |
| Journal name | Hypertension (Dallas, Tex. : 1979) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2024 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Publication date | 2023 08 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | ppublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Medline status | MEDLINE |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2023-08-15 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | BACKGROUND: Dyslipidemia is an important risk factor for hypertension and cardiovascular disease. Standard lipid panel cannot reflect the complexity of blood lipidome. The associations of individual lipid species with hypertension remain to be determined in large-scale epidemiological studies, especially in a longitudinal setting. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | CONCLUSIONS: Baseline plasma lipid species and their longitudinal changes are significantly associated with hypertension development in American Indians. Our findings shed light on the role of dyslipidemia in hypertension and may offer potential opportunities for risk stratification and early prediction of hypertension. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | METHODS: Using liquid chromatography-mass spectrometry, we repeatedly measured 1542 lipid species in 3699 fasting plasma samples at 2 visits (1905 at baseline, 1794 at follow-up, ~5.5 years apart) from 1905 unique American Indians in the Strong Heart Family Study. We first identified baseline lipids associated with prevalent and incident hypertension, followed by replication of top hits in Europeans. We then conducted repeated measurement analysis to examine the associations of changes in lipid species with changes in systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Network analysis was performed to identify lipid networks associated with the risk of hypertension. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | RESULTS: Baseline levels of multiple lipid species, for example, glycerophospholipids, cholesterol esters, sphingomyelins, glycerolipids, and fatty acids, were significantly associated with both prevalent and incident hypertension in American Indians. Some lipids were confirmed in Europeans. Longitudinal changes in multiple lipid species, for example, acylcarnitines, phosphatidylcholines, fatty acids, and triacylglycerols, were significantly associated with changes in blood pressure measurements. Network analysis identified distinct lipidomic patterns associated with the risk of hypertension. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | *Dyslipidemias |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | *Hypertension |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | American Indian or Alaska Native |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Fatty Acids |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hypertension/ep [Epidemiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Lipidomics |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Triglycerides |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Indexing | Automated |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Research Support, N.I.H., Extramural |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Howard, Barbara V |
| Institution Code | MHRI |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Umans, Jason G |
| Institution Code | MHRI |
| 790 ## - Authors | |
| All authors | Chen M, Fiehn O, Howard BV, Lee ET, Miao G, Umans JG, Zhang Y, Zhao J |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.1161/HYPERTENSIONAHA.123.21144">https://dx.doi.org/10.1161/HYPERTENSIONAHA.123.21144</a> |
| Public note | https://dx.doi.org/10.1161/HYPERTENSIONAHA.123.21144 |
| 858 ## - ORCID | |
| Name | https://orcid.org/0000-0002-2746-3350 |
| ORCID text | Umans, Jason G |
| Orcid | <a href="https://orcid.org/0000-0002-2746-3350">https://orcid.org/0000-0002-2746-3350</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
No items available.