Clinical and Histopathologic Features of 35 Patients Treated for Colorectal Peritoneal Metastases Who Survived 5 Years. (Record no. 13551)

MARC details
000 -LEADER
fixed length control field 07137nam a22007337a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 232233s20232023 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0012-3706
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 00003453-202310000-00009 [pii]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1097/DCR.0000000000002448 [doi]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 36856661
245 ## - TITLE STATEMENT
Title Clinical and Histopathologic Features of 35 Patients Treated for Colorectal Peritoneal Metastases Who Survived 5 Years.
251 ## - Source
Source Diseases of the Colon & Rectum. 66(10):1329-1338, 2023 Oct 01.
252 ## - Abbreviated Source
Abbreviated source Dis Colon Rectum. 66(10):1329-1338, 2023 Oct 01.
253 ## - Journal Name
Journal name Diseases of the colon and rectum
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2023
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2024
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2023 Oct 01
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Medline status MEDLINE
266 ## - Date added to catalog
Date added to catalog 2023-11-22
520 ## - SUMMARY, ETC.
Abstract BACKGROUND: Currently, patients with a limited extent of peritoneal metastases from colon and rectal cancer are treated by cytoreductive surgery combined with perioperative chemotherapy performed at experienced centers.
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Abstract CARACTERSTICAS CLNICAS E HISTOPATOLGICAS EN PACIENTES TRATADOS POR METASTASIS PERITONEALES DE ORGEN COLORECTAL Y QUE SOBREVIVIERON AOS: ANTECEDENTES:Actualmente, los pacientes con extension limitada de metastasis peritoneales de origen colorectal son tratados mediante cirugia citorreductora asociada con una quimioterapia peri-peratoria realizadas en centros experimentados.OBJETIVO:Estudio y evaluacion estadistica de las caracteristicas que puedan impactar en la sobrevida de los pacientes a 5 anos o mas. Se utilizaron estos datos en el analisis de riesgo /beneficio realizados por un equipo multidisciplinario.DISENO:Revision retrospectiva de una base de datos prospectiva.AJUSTES:Estudio realizado en una sola institucion academica.PACIENTES:Todos aquellos que presentaban metastasis peritoneales de origen colorectal, comprobadas por biopsia y tratadas con quimioterapia sistemica, cirugia peri-operatoria y citorreductora completas.MEDIDAS DE RESULTADO PRINCIPALES:Las medidads de resultados primarios fueron las caracteristicas clinicas, histologicas y relacionadas con el tratamiento que tuvieron un impacto en la sobrevida a 5 anos. RESULTADOS:De 131 pacientes que tuvieron una cirugia de citorreduccion completa, 35 pacientes (26, 7%) fueron identificados como sobrevivientes a 5 anos. La mediana de sobrevida fue de 27 meses. Se identificarion 16 varones. La mediana de edad fue de 50, 5 anos con un rango de 25 a 80 anos. Segun analisis univariante, la ausencia de compromiso de los ganglios linfaticos en el momento de la reseccion del cancer colorrectal primario (HR 1,899 (1,064, 3,388) p = 0,03), la respuesta completa o casi completa al tratamiento neoadyuvante con quimioterapia (HR 0,251 (0,092, 0,684) p = 0,007), el indice de cancer peritoneal <=17 (HR 0,509 (0,329, 0,788) p = 0,002), la reseccion completa y visible de la enfermedad indicada por la puntuacion de citorreduccion de 0 (HR 0,412 (0,224), 0,756) p = 0,004) y los tumores bien diferenciados (HR 0,34 (0,157, 0,737) p = 0,006) se asociaron significativamente con 5 o mas anos de sobrevida.LIMITACIONES:El estudio se encontro limitado por su naturaleza retrospectiva, por la no medida de factores de confusion y por los datos provenientes de una sola institucion. CONCLUSION ES:La biologia tumoral demostrada segun el estado de los ganglios linfaticos y la diferenciacion tumoral, agregada a la extension de la enfermedad medida por la respuesta a la quimioterapia neoadyuvante, el indice de cancer peritoneal y la ausencia visible de enfermedad residual, demostraron un resultado favorable. Consulte Video Resumen en http://links.lww.com/DCR/C62(Traduccion-Dr. Xavier Delgadillo ). Copyright © The ASCRS 2022.
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Abstract CONCLUSIONS: The tumor biology as revealed by lymph node status and tumor differentiation plus extent of disease as measured by the response to neoadjuvant chemotherapy, peritoneal cancer index, and no visible residual disease indicated a favorable outcome. See Video Abstract at http://links.lww.com/DCR/C62 .
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Abstract DESIGN: This was a retrospective review of a prospective database.
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Abstract LIMITATIONS: Limitations include its retrospective nature, unmeasured confounders, and data from a single institution.
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Abstract MAIN OUTCOME MEASURES: The primary outcomes measured were the clinical-, histologic-, and treatment-related features that had an impact on 5-year survival.
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Abstract OBJECTIVE: To statistically evaluate features that may impact survival of >=5 years. These data are used in the risk/benefit analyses performed by the multidisciplinary team.
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Abstract PATIENTS: All patients who had biopsy-proven colon or rectal peritoneal metastases treated by systemic chemotherapy, complete cytoreductive surgery, and perioperative surgery were included.
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Abstract RESULTS: From 131 patients who had complete cytoreduction, 35 patients (26.7%) were identified as 5-year survivors. The median survival time was 27 months. The median age was 50.5 (range, 25-80) years. By univariant analysis, an absence of lymph node involvement at the time of primary colorectal cancer resection (HR 1.899 [95% CI, 1.064-3.388]; p = 0.03), complete or near-complete response to neoadjuvant chemotherapy (HR 0.251 [95% CI, 0.092-0.684]; p = 0.007), peritoneal cancer index <=17 (HR 0.509 [95% CI, 0.329-0.788]; p = 0.002), complete visible resection of disease indicated by the completeness of cytoreduction score of 0 (HR 0.412 [95% CI, 0.224-0.756]; p = 0.004), and well-differentiated tumor (HR 0.34 [95% CI, 0.157-0.737]; p = 0.006) were significantly associated with >=5 years survival.
520 ## - SUMMARY, ETC.
Abstract SETTINGS: This single-institution study was conducted at an academic center.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Colorectal Neoplasms
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Hyperthermia, Induced
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Peritoneal Neoplasms
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adult
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Topical term or geographic name entry element Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged, 80 and over
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Colorectal Neoplasms/su [Surgery]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Combined Modality Therapy
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cytoreduction Surgical Procedures/ae [Adverse Effects]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hyperthermia, Induced/ae [Adverse Effects]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Peritoneal Neoplasms/sc [Secondary]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Peritoneum/pa [Pathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Peritoneum/su [Surgery]
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Topical term or geographic name entry element Prognosis
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Retrospective Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Survival Rate
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Indexing Curated
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution Washington Cancer Institute
656 ## - INDEX TERM--OCCUPATION
Department MedStar General Surgery Residency
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Department MedStar Georgetown University Hospital/MedStar Washington Hospital Center
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
657 ## - INDEX TERM--FUNCTION
Medline publication type Video-Audio Media
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Desale, Sameer
Institution Code MHRI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Ghabra, Shadin
Institution Code MGUH
Program MedStar General Surgery Residency
Degree MBBS
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Sugarbaker, Paul H
Institution Code WCI
790 ## - Authors
All authors Ghabra S, Desale S, Sugarbaker PH
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1097/DCR.0000000000002448">https://dx.doi.org/10.1097/DCR.0000000000002448</a>
Public note https://dx.doi.org/10.1097/DCR.0000000000002448
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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