MARC details
000 -LEADER |
fixed length control field |
03668nam a22005177a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
2401116s20232023 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
1082-0744 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.46292/sci23-00004 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
PMC10644857 [pmc] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
38076286 |
245 ## - TITLE STATEMENT |
Title |
Intravesical Lactobacillus rhamnosus GG Alters Urobiome Composition and Diversity Among People With Neurogenic Lower Urinary Tract Dysfunction. |
251 ## - Source |
Source |
Topics in Spinal Cord Injury Rehabilitation. 29(3):44-57, 2023 Summer. |
252 ## - Abbreviated Source |
Abbreviated source |
Top Spinal Cord Inj Rehabil. 29(3):44-57, 2023. |
253 ## - Journal Name |
Journal name |
Topics in spinal cord injury rehabilitation |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2023 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2024 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2023 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Medline status |
PubMed-not-MEDLINE |
266 ## - Date added to catalog |
Date added to catalog |
2024-01-16 |
520 ## - SUMMARY, ETC. |
Abstract |
Background: Neurogenic bladder is associated with bacterial colonization and frequent urinary tract infections. |
520 ## - SUMMARY, ETC. |
Abstract |
Conclusion: Among people with SCI/D who use IC, intravesical LGG alters the bacterial composition and diversity of the urine ecosystem, potentially disrupting the uropathogenic urobiome. Copyright © 2023 American Spinal Injury Association. |
520 ## - SUMMARY, ETC. |
Abstract |
Methods: This was a pilot substudy within an 18-month phase 1 clinical trial of self-instilled intravesical LGG for urinary symptoms as directed by the Self-Management Protocol using Probiotics (SMP-Pro). Urine samples were collected monthly when participants were asymptomatic. When SMP-Pro "trigger" symptoms (cloudier and/or more foul-smelling urine) occurred, urine samples were collected immediately pre-LGG instillation and 24 to 48 hours after LGG instillation. Urine was collected via a new catheter, immediately placed on ice/freezer, and processed within 12 hours. Genomic DNA was isolated, and the V4 region of the 16S rRNA bacterial gene was amplified and high throughput sequenced. Amplicon sequence variants were inferred and bacterial composition, community structure, and variation across clinical phenotypes were determined. |
520 ## - SUMMARY, ETC. |
Abstract |
Objectives: To explore the effects of one to two doses of intravesical Lactobacillus rhamnosus GG (LGG) on the urobiomes of adults with spinal cord injury/disease (SCI/D) who manage their bladders with intermittent catheterization (IC). |
520 ## - SUMMARY, ETC. |
Abstract |
Results: 126 urine samples were collected from 26 participants (SCI/D = 23; multiple sclerosis = 2; spina bifida = 1) between 20 and 57 years of age. The urobiomes were characterized by four dominant phyla (>1%): Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria, which were comprised of six dominant genera (>3%): Escherichia/Shigella (29.1%), Klebsiella (22.4%), Proteus (15.2%), Aerococcus (6.3%), Streptococcus (6.0%), and Pluralibacter (3.0%). Post-LGG samples were associated with a decline in Escherichia/Shigella predominance (p < .001) and altered bacterial diversity (p < .05). |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Lacticaseibacillus rhamnosus |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Microbiota |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Spinal Cord Injuries |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Urinary Bladder, Neurogenic |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Urinary Tract |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Adult |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
RNA, Ribosomal, 16S |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Spinal Cord Injuries/co [Complications] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Urinary Bladder, Neurogenic/th [Therapy] |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Health Research Institute |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar National Rehabilitation Network |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Groah, Suzanne |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Rounds, Amanda K |
Institution Code |
MNRN |
-- |
MHRI |
790 ## - Authors |
All authors |
Groah SL, Rounds AK, Perez-Losada M |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.46292/sci23-00004">https://dx.doi.org/10.46292/sci23-00004</a> |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |