MARC details
| 000 -LEADER |
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| fixed length control field |
03760nam a22004577a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
130912s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1094-8341 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
22186255 |
| 245 ## - TITLE STATEMENT |
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| Title |
Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects. |
| 251 ## - Source |
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| Source |
Physiological Genomics. 44(3):220-8, 2012 Feb 13. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Physiol Genomics. 44(3):220-8, 2012 Feb 13. |
| 253 ## - Journal Name |
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| Journal name |
Physiological genomics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2012 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2012 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2013-09-17 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Serum sodium concentration is the clinical index of systemic water balance. Although disordered water balance is common and morbid, little is known about genetic effects on serum sodium concentration at the population level. Prior studies addressed only participants of European descent and either failed to demonstrate significant heritability or showed only modest effect. We investigated heritability of serum sodium concentration in large cohorts reflecting a range of races/ethnicities, including the Framingham Heart Study (FHS, non-Hispanic Caucasian), the Heredity and Phenotype Intervention Heart Study (HAPI, Amish Caucasian), the Jackson Heart Study (JHS, African American), the Strong Heart Family Study (SHFS, American Indian), and the Genetics of Kidney Disease in Zuni Indians Study (GKDZI, American Indian). Serum sodium was transformed for the osmotic effect of glucose, and participants with markedly elevated glucose or reduced estimated glomerular filtration rate (eGFR) were excluded. Using a standard variance components method, incorporating covariates of age, glucose, and eGFR, we found heritability to be high in African American and American Indian populations and much more modest in non-Hispanic Caucasian populations. Estimates among females increased after stratification on sex and were suggestive among female participants in FHS (0.18 +/- 0.12, P = 0.057) and male participants in JHS (0.24 +/- 0.16, P = 0.067) and statistically significant among female participants in JHS (0.44 +/- 0.09, P = 1 x 10 -7), SHFS (0.59 +/- 0.05, P = 9.4 x 10-46), and GKDZI (0.46 +/- 0.15, P = 1.7 x 10-4), and male participants in HAPI (0.18 +/- 0.12, P = 0.03) and SHFS (0.67 +/- 0.07, P = 5.4 x 10-26). Exclusion of diuretic users increased heritability among females and was significant in all cohorts where data were available. In aggregate, these data strongly support the heritability of systemic water balance and underscore sex and ethnicity-specific effects. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*African Americans/ge [Genetics] |
| 9 (RLIN) |
814 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Amish/ge [Genetics] |
| 9 (RLIN) |
815 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*European Continental Ancestry Group/ge [Genetics] |
| 9 (RLIN) |
817 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Indians, North American/ge [Genetics] |
| 9 (RLIN) |
818 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Quantitative Trait, Heritable |
| 9 (RLIN) |
819 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Sodium/bl [Blood] |
| 9 (RLIN) |
820 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Water-Electrolyte Balance/ge [Genetics] |
| 9 (RLIN) |
821 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Age Factors |
| 9 (RLIN) |
712 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Analysis of Variance |
| 9 (RLIN) |
816 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cohort Studies |
| 9 (RLIN) |
187 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 9 (RLIN) |
7 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 9 (RLIN) |
11 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Male |
| 9 (RLIN) |
14 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Sex Factors |
| 9 (RLIN) |
499 |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Comparative Study |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Research Support, N.I.H., Extramural |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Umans, Jason G |
| 9 (RLIN) |
561 |
| 790 ## - Authors |
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| All authors |
Chang YP, Chen Z, Cohen DM, Cole SA, Comuzzie AG, Flessner MF, Fu Y, Gipson T, Hitzemann R, Maccluer JW, McWeeney S, Shah VO, Shuldiner AR, Taylor HA, Umans JG, Voruganti VS, Wilmot B, Wilson JG, Zager PG |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1152/physiolgenomics.00153.2011">http://dx.doi.org/10.1152/physiolgenomics.00153.2011</a> |
| Public note |
http://dx.doi.org/10.1152/physiolgenomics.00153.2011 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Source of classification or shelving scheme |
Other/Generic Classification Scheme |
| Item type description |
Article |
