Whole blood gene expression testing for coronary artery disease in nondiabetic patients: major adverse cardiovascular events and interventions in the PREDICT trial. (Record no. 1396)

MARC details
000 -LEADER
fixed length control field 03586nam a22006857a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130913s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 22396313
245 ## - TITLE STATEMENT
Title Whole blood gene expression testing for coronary artery disease in nondiabetic patients: major adverse cardiovascular events and interventions in the PREDICT trial.
251 ## - Source
Source Journal of Cardiovascular Translational Research . 5(3):366-74, 2012 Jun.
252 ## - Abbreviated Source
Abbreviated source J Cardiovasc Transl Res. 5(3):366-74, 2012 Jun.
253 ## - Journal Name
Journal name Journal of cardiovascular translational research
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2012
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2012
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Date added to catalog 2013-09-17
520 ## - SUMMARY, ETC.
Abstract The majority of first-time angiography patients are without obstructive coronary artery disease (CAD). A blood gene expression score (GES) for obstructive CAD likelihood was validated in the PREDICT study, but its relation to major adverse cardiovascular events (MACE) and revascularization was not assessed. Patients (N = 1,160) were followed up for MACE and revascularization 1 year post-index angiography and GES, with 1,116 completing follow-up. The 30-day event rate was 23% and a further 2.2% at 12 months. The GES was associated with MACE/revascularizations (p < 0.001) and added to clinical risk scores. Patients with GES >15 trended towards increased >30 days MACE/revascularization likelihood (odds ratio = 2.59, 95% confidence interval = 0.89-9.14, p = 0.082). MACE incidence overall was 1.5% (17 of 1,116) and 3 of 17 patients had GES <= 15. For the total low GES group (N = 396), negative predictive value was 90% for MACE/revascularization and >99% for MACE alone, identifying a group of patients without obstructive CAD and highly unlikely to suffer MACE within 12 months.
546 ## - LANGUAGE NOTE
Language note English
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Topical term or geographic name entry element *Coronary Artery Disease/di [Diagnosis]
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Topical term or geographic name entry element *Genetic Testing
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Topical term or geographic name entry element Adult
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Topical term or geographic name entry element Aged
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Topical term or geographic name entry element Aged, 80 and over
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Angioplasty, Balloon, Coronary
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronary Angiography
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronary Artery Bypass
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Topical term or geographic name entry element Coronary Artery Disease/co [Complications]
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Topical term or geographic name entry element Coronary Artery Disease/ge [Genetics]
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Topical term or geographic name entry element Coronary Artery Disease/mo [Mortality]
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Topical term or geographic name entry element Coronary Artery Disease/ra [Radiography]
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Topical term or geographic name entry element Coronary Artery Disease/th [Therapy]
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Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Gene Expression Regulation
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Topical term or geographic name entry element Genetic Predisposition to Disease
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Topical term or geographic name entry element Humans
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Topical term or geographic name entry element Ischemic Attack, Transient/et [Etiology]
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Topical term or geographic name entry element Logistic Models
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Topical term or geographic name entry element Male
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Topical term or geographic name entry element Middle Aged
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Topical term or geographic name entry element Myocardial Infarction/et [Etiology]
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Topical term or geographic name entry element Odds Ratio
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Topical term or geographic name entry element Phenotype
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Topical term or geographic name entry element Predictive Value of Tests
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Topical term or geographic name entry element Prognosis
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Topical term or geographic name entry element Prospective Studies
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Topical term or geographic name entry element Reproducibility of Results
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Topical term or geographic name entry element Risk Assessment
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Topical term or geographic name entry element Risk Factors
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Topical term or geographic name entry element Stroke/et [Etiology]
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Topical term or geographic name entry element Time Factors
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Topical term or geographic name entry element United States
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Heart & Vascular Institute
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Medline publication type Journal Article
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Medline publication type Multicenter Study
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Medline publication type Research Support, N.I.H., Extramural
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Medline publication type Research Support, Non-U.S. Gov't
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Waksman, Ron
790 ## - Authors
All authors Brown BO, Elashoff MR, Ellis SG, Kraus WE, Lansky AJ, Lieu HD, McPherson JA, PREDICT Investigators, Rosenberg S, Schwartz RS, Topol EJ, Voros S, Waksman R
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DOI <a href="http://dx.doi.org/10.1007/s12265-012-9353-z">http://dx.doi.org/10.1007/s12265-012-9353-z</a>
Public note http://dx.doi.org/10.1007/s12265-012-9353-z
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 09/17/2013   22396313 22396313 09/17/2013 09/17/2013 Journal Article

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