MARC details
| 000 -LEADER |
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| fixed length control field |
03480nam a22004937a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
240723s20242024 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0003-1348 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
38655912 |
| 245 ## - TITLE STATEMENT |
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| Title |
Predictors of Timely Initiation and Completion of Adjuvant Chemotherapy in Stage II/III Colorectal Adenocarcinoma. |
| 251 ## - Source |
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| Source |
American Surgeon. :31348241248689, 2024 Apr 24 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Am Surg. :31348241248689, 2024 Apr 24 |
| 253 ## - Journal Name |
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| Journal name |
The American surgeon |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2024 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2024 Apr 24 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
Publisher |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2024-07-23 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online through MWHC library: 2005 - present, Available in print through MWHC library:1999-2007 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Background: Adjuvant chemotherapy (AC) for colorectal cancer (CRC) has led to substantial improvement in survival. Several clinical trials advocate the initiation of AC within 6-8 weeks of surgical resection based on evidence of improved survival with early initiation of AC. We aim to evaluate factors that predict initiation and completion of AC, subsequently improving survival. Methods: We identified 451 patients who underwent resection for CRC between 2014 and 2022. One hundred ten patients had stage II/III colorectal cancer who underwent resection followed by AC. Multivariable logistic regression analysis was performed to identify factors significantly predicting delay in AC >8 weeks. Secondary outcomes included chemotherapy completion rate, recurrence-free survival, and overall survival. Results: The final analysis included 110 patients. The median time to initiation of adjuvant chemotherapy (TIAC) was 6.9 weeks (IQR: 5.8-9.5). In total, 36.4% of patients had a delay >8 weeks to initiation of AC, and only 40% completed treatment. The surgical approach (open vs laparoscopic vs robotic) had no effect on the TIAC. On multivariable logistic regression analysis, preoperative albumin >=3.5 (OR = .31; 95% CI: .12-.80) was an independent predictor of timely initiation of AC. Completion of AC was associated with a higher overall survival. Discussion: Preoperative nutritional status predicted delay in initiation of AC. Patients with a delay in AC beyond eight weeks had a lower rate of AC completions and worse survival. It is imperative to optimize this aspect of treatment as it correlates with survival. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Indexing |
Automated |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Franklin Square Medical Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
General Surgery Residency |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Surgery |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Almanzar, Anyelin |
| Institution Code |
MFSMC |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Alnajjar, Said |
| Institution Code |
MFSMC |
| Program |
General Surgery Residency |
| Degree |
MD |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Gupta, Vinay |
| Institution Code |
MSFMC |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Lisle, David |
| Institution Code |
MFSMC |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shoucair, Sami |
| Institution Code |
MFSMC |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Zheng, Kan |
| Institution Code |
MFSMC |
| 790 ## - Authors |
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| All authors |
Alnajjar S, Shoucair S, Almanzar A, Zheng K, Lisle D, Gupta V |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1177/00031348241248689">https://dx.doi.org/10.1177/00031348241248689</a> |
| Public note |
https://dx.doi.org/10.1177/00031348241248689 |
| 858 ## - ORCID |
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| ORCID text |
Almanzar, Anyelin; RINGGOLD: 23435 |
| Name |
https://orcid.org/0009-0002-1747-2410 |
| 858 ## - ORCID |
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| ORCID text |
Alnajjar, Said |
| Orcid |
<a href="https://orcid.org/0009-0002-1747-2410">https://orcid.org/0009-0002-1747-2410</a> |
| 858 ## - ORCID |
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| ORCID text |
Alnajjar, Said; RINGGOLD: 23435 |
| 858 ## - ORCID |
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| ORCID text |
Gupta, Vinay; RINGGOLD: 23435 |
| 858 ## - ORCID |
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| ORCID text |
Lisle, David; RINGGOLD: 23435 |
| 858 ## - ORCID |
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| ORCID text |
Shoucair, Sami; RINGGOLD: 23435 |
| 858 ## - ORCID |
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| ORCID text |
Zheng, Kan; RINGGOLD: 23435 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
