MARC details
| 000 -LEADER |
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| fixed length control field |
03495nam a22004577a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
240807s20242024 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2057-3804 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1186/s40959-024-00234-0 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC11100143 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
38760863 |
| 245 ## - TITLE STATEMENT |
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| Title |
Immune checkpoint inhibitors and pericardial disease: a systematic review. |
| 251 ## - Source |
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| Source |
Cardio-Oncology. 10(1):29, 2024 May 17. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Cardiooncology. 10(1):29, 2024 May 17. |
| 253 ## - Journal Name |
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| Journal name |
Cardio-oncology (London, England) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2024 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2024 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2024 May 17 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
PubMed-not-MEDLINE |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2024-08-07 |
| 266 ## - Date added to catalog |
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| Date Medline record created |
2024/05/17 23:42 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
DISCUSSION: This study provides the most comprehensive analysis of ICI-mediated pericardial disease to date. Patients affected were most commonly male with lung cancer treated with either Nivolumab or Pembrolizumab. Diagnosis may be challenging in the setting of occult presentation with normal EKG and physical exam as well as delayed onset from therapy initiation. ICI-associated pericardial disease demonstrates high morbidity and mortality, as evidenced by a majority of patients requiring pericardiocentesis. Copyright © 2024. The Author(s). |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
INTRODUCTION: Despite the growing use of immune checkpoint inhibitors (ICI) in cancer treatment, data regarding ICI-associated pericardial disease are primarily derived from case reports and case series. ICI related pericardial disease can be difficult to diagnose and is associated with significant morbidity. We conducted a systematic review to further characterize the epidemiology, clinical presentation, and outcomes of this patient population. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: A search of four databases resulted in 31 studies meeting inclusion criteria. Patients > 18 years old who presented with ICI mediated pericardial disease were included. Intervention was medical + surgical therapy and outcomes were development of cardiac tamponade, morbidity, and mortality. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: Thirty- eight patients across 31 cases were included. Patients were majority male (72%) with a median age of 63. Common symptoms included dyspnea (59%) and chest pain (32%), with 41% presenting with cardiac tamponade. Lung cancer (81%) was the most prevalent, and nivolumab (61%) and pembrolizumab (34%) were the most used ICIs. Pericardiocentesis was performed in 68% of patients, and 92% experienced symptom improvement upon ICI cessation. Overall mortality was 16%. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Indexing |
Automated |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Internal Medicine Residency |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
MedStar Georgetown University Hospital/MedStar Washington Hospital Center |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kumar, Ashwin |
| Institution Code |
MGUH |
| Program |
Internal Medicine Residency |
| Degree |
DO |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Li, Jason |
| Institution Code |
MGUH |
| Program |
Internal Medicine Residency |
| Degree |
MD |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
McGowan, Kevin |
| Institution Code |
MGUH |
| Program |
Internal Medicine Residency |
| Degree |
MD |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Mudra, Sarah |
| Institution Code |
MGUH |
| Program |
Internal Medicine Residency |
| Degree |
MD |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Njus, Meredith |
| Institution Code |
MGUH |
| Program |
Internal Medicine Residency |
| Degree |
MD |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Rayes, Danny |
| Institution Code |
MGUH |
| Program |
Internal Medicine Residency |
| Degree |
MD |
| 790 ## - Authors |
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| All authors |
Mudra SE, Rayes DL, Agrawal A, Kumar AK, Li JZ, Njus M, McGowan K, Kalam KA, Charalampous C, Schleicher M, Majid M, Syed A, Yesilyaprak A, Klein AL |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1186/s40959-024-00234-0">https://dx.doi.org/10.1186/s40959-024-00234-0</a> |
| Public note |
https://dx.doi.org/10.1186/s40959-024-00234-0 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
