MARC details
| 000 -LEADER |
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| fixed length control field |
03256nam a22004217a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
240807s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2218-6778 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC11093044 [pmc] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
tbcr-03-29 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
38751542 |
| 245 ## - TITLE STATEMENT |
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| Title |
Reduction in tumor grade and Ki-67 in postmenopausal patient with node-positive invasive ductal carcinoma following combination hormone replacement therapy cessation: a case report. |
| 251 ## - Source |
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| Source |
Translational Breast Cancer Research : A Journal Focusing on Translational Research in Breast Cancer. 3:29, 2022. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Transl Breast Cancer Res. 3:29, 2022. |
| 253 ## - Journal Name |
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| Journal name |
Translational breast cancer research : a journal focusing on translational research in breast cancer |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2022 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
PubMed-not-MEDLINE |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2024-08-07 |
| 266 ## - Date added to catalog |
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| Date Medline record created |
2024/05/16 03:36 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Background: While praised for its benefits in treating symptoms related to menopausal changes, hormone replacement therapy (HRT) has been associated with an increased risk for hormone-dependent cancer development, particularly endometrial and breast. Few studies have elucidated the relationship between HRT cessation and hormone receptor-positive breast cancer proliferation. We report herein, to the best of our knowledge, the first case of 28.6% relative reduction in proliferation index marker Ki-67 in node-positive hormone receptor-positive breast cancer following HRT cessation. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Case Description: We report an unusual case of a 64-year-old female patient with longstanding HRT for fifteen years who underwent immediate discontinuation after diagnosis of poorly differentiated invasive ductal carcinoma. We observed a reduction in tumor grade from poorly differentiated at time of biopsy to moderately differentiated at time of surgery following cessation of HRT, as well as a reduction in the tumor proliferation index (Ki-67) from 70% to 50%. The patient has remained recurrence-free at the one-year mark postoperatively with continued follow-up. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Conclusions: This case highlights potential clinical benefits associated with HRT discontinuation in the postmenopausal population with preexisting hormone-dependent cancers with high proliferation index, as well as the usefulness of Ki-67 in measuring response to aromatase inhibition in this subpopulation of patients. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Keywords: Hormone replacement therapy (HRT); breast cancer; tumor grade; Ki-67; case report. Copyright 2022 Translational Breast Cancer Research. All rights reserved. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Indexing |
Automated |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
MedStar General Surgery Residency |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
MedStar Georgetown University Hospital/MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Surgery/Plastic Surgery |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Case Reports |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Fan, Kenneth L |
| Institution Code |
MWHC |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Masanam, Monika |
| Institution Code |
MGUH |
| Program |
MedStar General Surgery Residency |
| Degree |
MD |
| 790 ## - Authors |
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| All authors |
King CA, Masanam MK, Maini AS, Merritt CM, Fan KL, Greenwalt IT |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.21037/tbcr-22-26">https://dx.doi.org/10.21037/tbcr-22-26</a> |
| Public note |
https://dx.doi.org/10.21037/tbcr-22-26 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
