A retrospective cohort study comparing reconstructive techniques and outcomes in post-mastectomy triple negative breast cancer patients. (Record no. 14505)

MARC details
000 -LEADER
fixed length control field 04103nam a22004337a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 240807s20232023 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 2218-6778
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC11093065 [pmc]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code tbcr-04-5 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 38751478
245 ## - TITLE STATEMENT
Title A retrospective cohort study comparing reconstructive techniques and outcomes in post-mastectomy triple negative breast cancer patients.
251 ## - Source
Source Translational Breast Cancer Research : A Journal Focusing on Translational Research in Breast Cancer. 4:5, 2023.
252 ## - Abbreviated Source
Abbreviated source Transl Breast Cancer Res. 4:5, 2023.
253 ## - Journal Name
Journal name Translational breast cancer research : a journal focusing on translational research in breast cancer
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2023
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2023
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status epublish
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Medline status PubMed-not-MEDLINE
266 ## - Date added to catalog
Date added to catalog 2024-08-07
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Date Medline record created 2024/05/16 03:35
520 ## - SUMMARY, ETC.
Abstract Background: Up to 42% of all breast cancer patients undergo post-mastectomy reconstruction, however reconstructive techniques have not been widely studied in patients with triple negative breast cancer (TNBC). Reconstructive complications may delay adjuvant treatments; in TNBC, which inherently carries an increased risk of locoregional recurrence, this can greatly affect oncological outcomes. Therefore, we evaluate factors influencing choice of reconstructive techniques following mastectomy in TNBC patients and assess operative and oncologic safety outcomes.
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Abstract Conclusions: Factors such as age, BMI, and breast cancer history impacted choice of reconstructive technique among TNBC women. No differences in complications, recurrence, or mortality occur in these high-risk patients regardless of reconstructive technique, highlighting that neither ABR nor IBR is superior in regard to surgical and oncologic safety in post-mastectomy TNBC patients. Copyright 2023 Translational Breast Cancer Research. All rights reserved.
520 ## - SUMMARY, ETC.
Abstract Methods: A single institution retrospective chart review identified TNBC patients who underwent post-mastectomy reconstruction between 2010 to 2020. Clinical characteristics collected included demographics, cancer history, reconstructive techniques [autologous-based reconstruction (ABR) vs. implant-based reconstruction (IBR)] and surgical and oncologic outcomes such as complications, recurrence, and mortality. Factors impacting whether patients underwent ABR versus IBR were assessed, as well as differences in outcomes between the two procedures. Statistical significance was defined as P<0.05.
520 ## - SUMMARY, ETC.
Abstract Results: During the 10-year period, 52.9% (n=127) of all post-mastectomy TNBC patients (n=240) underwent breast reconstruction, most frequently immediately after mastectomy (97.0%). Most patients underwent IBR compared to ABR (82.4% vs. 14.5%). Patients undergoing ABR were older than IBR patients (54.3 vs. 46.4 years; P=0.040) and had a higher body mass index (BMI; 30.0 vs. 26.1 kg/m2; P=0.007). Patients more often pursued ABR if they had a prior breast cancer history (36.8% vs. 16.7%; P=0.041) or experienced TNBC recurrence (26.3% vs. 9.3%; P=0.034), while primary TNBC patients more often opted for IBR. Reconstructive type did not impact complications (ABR 31.6% vs. IBR 16.8%, P=0.131), recurrence (ABR 15.8% vs. IBR 13.0%, P=0.719), or mortality (ABR 0.0% vs. IBR 6.5%, P=0.593) rates.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Indexing Automated
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Washington Hospital Center
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Department MedStar General Surgery Residency
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Department MedStar Georgetown University Hospital/MedStar Washington Hospital Center
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Department Surgery/Plastic Surgery
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Medline publication type Journal Article
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Local Authors Deldar, Romina
Institution Code MGUH
Program MedStar General Surgery Residency
Degree MD
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Fan, Kenneth L
Institution Code MWHC
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Masanam, Monika
Institution Code MGUH
Program MedStar General Surgery Residency
Degree MD
790 ## - Authors
All authors Sayyed AA, Towfighi P, Deldar R, Aminpour N, Sogunro O, Maini M, Masanam M, Son JD, Fan KL, Song DH
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.21037/tbcr-22-42">https://dx.doi.org/10.21037/tbcr-22-42</a>
Public note https://dx.doi.org/10.21037/tbcr-22-42
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Barcode Date last seen Price effective from Koha item type
              08/07/2024   38751478 08/07/2024 08/07/2024 Journal Article

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