MARC details
| 000 -LEADER |
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| fixed length control field |
02939nam a22004697a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160715s20132013 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0021-8782 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
24033117 |
| 245 ## - TITLE STATEMENT |
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| Title |
A stereologic study of the plantar fat pad in young and aged rats. |
| 251 ## - Source |
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| Source |
Journal of Anatomy. 223(5):537-45, 2013 Nov. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J Anat. 223(5):537-45, 2013 Nov. |
| 253 ## - Journal Name |
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| Journal name |
Journal of anatomy |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2013 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2014 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2016-07-15 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1916 - 2005 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Plantar fat pad (PFP) is a tissue structure that absorbs the initial impact of walking and running and ultimately bears body weight at standing. This study was designed to quantify the histomorphological changes of the PFP in aged rats. The most medial PFP was dissected from the hind feet of young rats (4 months old, n = 6) and aged rats (24 months old, n = 6). Histological structure and cellular senescence of PFP were analyzed stereologically and histomorphometrically. Immunohistochemistry of matrix metalloproteinase 9 (MMP9) was also performed on PFP tissue sections. Compared with young rats, the thickness of epidermis, dermis and septa of the PFP were significantly reduced in the aged rats. The total volume of adipose tissue in the PFP of aged rats was only about 65% of that in the young rats. The microvascular density and the number of fat pad units (FPU), a cluster of adipocytes enclosed by elastin septa, in the PFP were unchanged in the aged rats. In the aged rats, the number of adipocytes per FPU was reduced but the number of simple adipocyte clusters, without surrounding septa, was increased. The shift of the types of adipocyte clusters in the aged PFP was accompanied by degradation of elastin fibers and increased expression of MMP9. In conclusion, the PFP, particularly the elastic septa, degenerates significantly in aged rats and this may contribute to the pathology of PFP-related diseases. Copyright © 2013 Anatomical Society. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Adipose Tissue/ah [Anatomy & Histology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Aging/ph [Physiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Foot/ah [Anatomy & Histology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adipocytes/cy [Cytology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Animals |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Immunohistochemistry |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Male |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Matrix Metalloproteinase 9/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Rats |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Rats, Long-Evans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Skin/ah [Anatomy & Histology] |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Union Memorial Hospital |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Orthobiologic Laboratory |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Orthopaedic Surgery |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Research Support, Non-U.S. Gov't |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Molligan, Jeremy |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Schon, Lew C |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Zhang, Zijun |
| 790 ## - Authors |
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| All authors |
Molligan J, Schon L, Zhang Z |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1111/joa.12104">http://dx.doi.org/10.1111/joa.12104</a> |
| Public note |
http://dx.doi.org/10.1111/joa.12104 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
