MARC details
| 000 -LEADER |
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| fixed length control field |
03028nam a22003377a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170428s20172017 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1538-7836 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
28378522 |
| 245 ## - TITLE STATEMENT |
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| Title |
Plasminogen activator inhibitor-1 is associated with leukocyte telomere length in American Indians: findings from the Strong Heart Family Study. |
| 251 ## - Source |
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| Source |
Journal of Thrombosis & Haemostasis. , 2017 Apr 05 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J Thromb Haemost. , 2017 Apr 05 |
| 253 ## - Journal Name |
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| Journal name |
Journal of thrombosis and haemostasis : JTH |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2017 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2017 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2017-05-06 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) promotes cellular aging both in vitro and in vivo. Telomere length is a marker of biological aging. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: A higher level of plasma PAI-1 was associated with shorter LTL in American Indians. This finding may suggest a potential role of PAI-1 in biological aging among American Indians. This article is protected by copyright. All rights reserved. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Copyright This article is protected by copyright. All rights reserved. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: We measured leukocyte telomere length (LTL) and plasma PAI-1 in 2,560 American Indians who were free of overt CVD and participated in the Strong Heart Family Study (SHFS) clinical exam in 2001-2003. LTL and PAI-1 were repeatedly measured in 475 participants who attended SHFS clinical visits in both 2001-2003 and 1998-1999. Generalized estimating equation model was used to examine the cross-sectional and longitudinal associations between PAI-1 and LTL, adjusting for known risk factors. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
OBJECTIVES: To examine the cross-sectional and longitudinal associations between plasma PAI-1 and leukocyte telomere length in a large-scale epidemiological study of American Indians. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: A higher level of plasma PAI-1 was negatively associated with shorter age-adjusted LTL (beta=-0.023, 95%CI: -0.034 ~ -0.013). This association was attenuated (beta=-0.015, 95%CI: -0.029 ~ -0.002) after adjustments for demographics, study site, lifestyle (smoking, drinking, physical activity), and metabolic factors (obesity, blood pressure, fasting glucose, insulin, lipids, kidney function). Further adjustment for hsCRP did not change this association (beta=-0.015, 95%CI: -0.029 ~ -0.001). Longitudinal analysis revealed that change in plasma PAI-1 was also inversely associated with change in LTL after adjusting for demographics, follow-up years, lifestyle factors, changes in metabolic factors, baseline levels of PAI-1 and LTL (beta=-0.0005, 95%CI: -0.0009 ~ -0.0001). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Howard, Barbara V |
| 790 ## - Authors |
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| All authors |
Best LG, Cole SA, Howard BV, Lee ET, Lin J, Peng H, Yeh F, Zhao J |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1111/jth.13689">https://dx.doi.org/10.1111/jth.13689</a> |
| Public note |
https://dx.doi.org/10.1111/jth.13689 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
