MARC details
| 000 -LEADER |
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| fixed length control field |
03083nam a22003617a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
221018s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0041-1132 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1111/trf.17069 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
36004803 |
| 245 ## - TITLE STATEMENT |
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| Title |
Detection of allergic transfusion-related adverse events from electronic medical records. |
| 251 ## - Source |
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| Source |
Transfusion. 2022 Aug 25 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Transfusion. 2022 Aug 25 |
| 253 ## - Journal Name |
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| Journal name |
Transfusion |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2022 Aug 25 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2022-10-20 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: Transfusion-related adverse events can be unrecognized and unreported. As part of the US Food and Drug Administration's Center for Biologics Evaluation and Research Biologics Effectiveness and Safety initiative, we explored whether machine learning methods, such as natural language processing (NLP), can identify and report transfusion allergic reactions (ARs) from electronic health records (EHRs). |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
DISCUSSION: NLP algorithms can identify transfusion reactions from the EHR with a reasonable level of precision for subsequent clinician review and confirmation. Copyright © 2022 AABB. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: Clinician reviews of selected validation cases yielded a sensitivity of 67.9% and a specificity of 97.5% at a threshold of 0.9, with a positive predictive value (PPV) of 84%, estimated to 4.5% when extrapolated to match transfusion AR incidence in the full transfusion dataset. A higher threshold achieved sensitivity of 43% with specificity/PPV of 100% in our validation set. Essential features predicting ARs were recognized transfusion reactions, administration of antihistamines or glucocorticoids, and skin symptoms (e.g., hives and itching). Removal of NLP features decreased model performance. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
STUDY DESIGN AND METHODS: In a 4-year period, all 146 reported transfusion ARs were pulled from a database of 86,764 transfusions in an academic health system, along with a random sample of 605 transfusions without reported ARs. Structured and unstructured EHR data were retrieved, including demographics, new symptoms, medications, and lab results. In unstructured data, evidence from clinicians' notes, test results, and prescriptions fields identified transfusion ARs, which were used to extract NLP features. Clinician reviews of selected validation cases assessed and confirmed model performance. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Institute for Innovation |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
National Center for Human Factors in Healthcare |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Hettinger, A Zachary |
| Institution Code |
NCHF |
| 790 ## - Authors |
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| All authors |
Anderson S, Belov A, Billings D, Cook K, Deady M, Ezzeldin H, Hettinger AZ, Kanderian S, Pizarro J, Whitaker B, Williams A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1111/trf.17069">https://dx.doi.org/10.1111/trf.17069</a> |
| Public note |
https://dx.doi.org/10.1111/trf.17069 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
