MARC details
| 000 -LEADER |
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| fixed length control field |
02481nam a22003017a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170918s20172017 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0031-4005 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
28864554 |
| 245 ## - TITLE STATEMENT |
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| Title |
Dietary Supplements, Isotretinoin, and Liver Toxicity in Adolescents: A Retrospective Case Series. |
| 251 ## - Source |
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| Source |
Pediatrics. , 2017 Sep 01 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Pediatrics. , 2017 Sep 01 |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
Replace Date, check full-text |
| 253 ## - Journal Name |
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| Journal name |
Pediatrics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2017 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2018 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2017-09-18 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from the MWHC library: 1948 - present, Available in print through MWHC library: 1999 - 2006 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Isotretinoin is the most effective acne therapy available, but has the potential for a number of adverse side effects, including transaminitis. The iPLEDGE isotretinoin program recommends avoiding some herbals and supplements due to potential side effects. However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We designed a retrospective chart review to evaluate the symptoms, diagnosis, treatment, and outcome of patients on or preparing to take isotretinoin therapy who were concurrently ingesting protein or herbal supplementation and who developed transaminitis. In 100% (8/8) of cases, dietary supplementation was determined to be at least a possible cause of elevated liver transaminases. In 75% (6/8) of cases, dietary supplement appears to be the most likely cause at some point in their evaluation. Most of our patients' elevations in aspartate aminotransferase and/or alanine aminotransferase were likely caused by supplementation with protein, creatine, or herbal extracts, rather than prescribed isotretinoin or tetracycline antibiotics for acne. Hence, dietary supplementation may cause liver function abnormalities. As supplement usage appears common in teenagers, clinicians should consider counseling their patients to avoid these products, particularly when prescribing known hepatotoxic drugs. Copyright (c) 2017 by the American Academy of Pediatrics. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Dermatology Marie Carver |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
DeKlotz, Cynthia |
| 790 ## - Authors |
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| All authors |
DeKlotz CMC, Friedlander SF, Roby KD |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1542/peds.2015-2940">https://dx.doi.org/10.1542/peds.2015-2940</a> |
| Public note |
https://dx.doi.org/10.1542/peds.2015-2940 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
