MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03190nam a22004337a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
170922s20172017 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
0021-972X |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
28911144 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Randomized Trial Comparing Two Algorithms for Levothyroxine Dose Adjustment in Pregnant Women With Primary Hypothyroidism. |
| 251 ## - Source |
|---|
| Source |
Journal of Clinical Endocrinology & Metabolism. 102(9):3499-3507, 2017 Sep 01 |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
J Clin Endocrinol Metab. 102(9):3499-3507, 2017 Sep 01 |
| 253 ## - Journal Name |
|---|
| Journal name |
The Journal of clinical endocrinology and metabolism |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2017 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2018 |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2017-09-22 |
| 501 ## - WITH NOTE |
|---|
| Local holdings |
Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006 |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Conclusions: We compared two options for LT4 dose adjustment and showed that an ongoing adjustment approach is as effective as empiric dose increase for maintaining goal TSH in hypothyroid women during pregnancy. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Context: Regulation of maternal thyroid hormones during pregnancy is crucial for optimal maternal and fetal outcomes. There are no specific guidelines addressing maternal levothyroxine (LT4) dose adjustments throughout pregnancy. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Design: Thirty-three women on stable LT4 doses were recruited at <10 weeks gestation during 38 pregnancies and randomized to one of two dose-adjustment groups. Group 1 (G1) used an empiric two-pill/week dose increase followed by subsequent pill-per-week dose adjustments. In group 2 (G2), LT4 dose was adjusted in an ongoing approach in micrograms per day based on current thyroid stimulating hormone (TSH) level and LT4 dose. TSH was monitored every 2 weeks in trimesters 1 and 2 and every 4 weeks in trimester 3. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Main Outcome Measure: Proportion of TSH values within trimester-specific goal ranges. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Objective: To compare two LT4 dose-adjustment algorithms in hypothyroid pregnant women. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Results: Mean gestational age at study entry was 6.4 +/- 2.1 weeks. Seventy-five percent of TSH values were within trimester-specific goal ranges in G1 compared with 81% in G2 (P = 0.09). Similar numbers of LT4 dose adjustments per pregnancy were required in both groups (G1, 3.1 +/- 2.0 vs G2, 4.1 +/- 3.2; P = 0.27). Women in G1 were more likely to have suppressed TSH <0.1 mIU/L in trimester 1 (P = 0.01). Etiology of hypothyroidism, but not thyroid antibody status, was associated with proportion of goal TSH values. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Setting: Academic endocrinology clinics in Washington, DC. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Medicine/Endocrinology |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Burman, Kenneth D |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Downs, Erin |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Jonklaas, Jacqueline |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Popoveniuc, Geanina |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Sullivan, Shannon D |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Zeymo, Alexander |
| 790 ## - Authors |
|---|
| All authors |
Burman KD, Downs E, Jonklaas J, Popoveniuc G, Sullivan SD, Zeymo A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1210/jc.2017-01086">https://dx.doi.org/10.1210/jc.2017-01086</a> |
| Public note |
https://dx.doi.org/10.1210/jc.2017-01086 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
