MARC details
000 -LEADER |
fixed length control field |
03985nam a22005777a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
170918s20172017 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
1061-4036 |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
28869590 |
245 ## - TITLE STATEMENT |
Title |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. |
251 ## - Source |
Source |
Nature Genetics. 49(10):1450-1457, 2017 Oct |
252 ## - Abbreviated Source |
Abbreviated source |
Nat Genet. 49(10):1450-1457, 2017 Oct |
253 ## - Journal Name |
Journal name |
Nature genetics |
253 ## - Journal Name |
Journal name |
Nature genetics |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2017 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2018 |
266 ## - Date added to catalog |
Date added to catalog |
2017-09-18 |
520 ## - SUMMARY, ETC. |
Abstract |
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Coronary Disease/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Diabetes Mellitus, Type 2/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Genome-Wide Association Study |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Asia/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Asian Continental Ancestry Group/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Biomarkers |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Comorbidity |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Coronary Disease/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Coronary Disease/et [Etiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Diabetes Mellitus, Type 2/dt [Drug Therapy] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Diabetes Mellitus, Type 2/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Diabetes Mellitus, Type 2/et [Etiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Europe/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
European Continental Ancestry Group/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Genetic Loci/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Genetic Predisposition to Disease |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
HLA-DRB5 Chains/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Metabolic Networks and Pathways/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Metabolic Syndrome X/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Metabolic Syndrome X/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Molecular Targeted Therapy |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Mutation, Missense |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Polymorphism, Single Nucleotide |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Risk Factors |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Health Research Institute |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Epstein, Stephen E |
790 ## - Authors |
All authors |
Abbas S, Ahmed N, Alam DS, Anand S, Asma S, Assimes TL, Benn M, Bottinger EP, Butterworth AS, Chambers JC, CHD Exome+ Consortium, Chen P, Chen YI, Chowdhury R, Chung RH, Damrauer S, Danesh J, Di Angelantonio E, EPIC-CVD Consortium, EPIC-Interact Consortium, Epstein S, Frikke-Schmidt R, Frossard P, Guo X, Howson JMM, Hsiung CA, Hsu CC, Hung YJ, Imamura M, Imran A, Iqbal W, Jabeen S, Juang JJ, Jukema JW, Kadowaki T, Kamstrup PR, Kooner JS, Kuo JZ, Lee IT, Lee JJ, Lee WJ, Liang KW, Loos RJF, Lu Y, Maeda S, Majeed F, Malik U, Mallick NH, Mehmood K, Mehra N, Melander O, Memon A, Memon FU, Michigan Biobank, Nielsen SF, Nordestgaard BG, Orho-Melander M, Pare G, Qamar N, Quertermous T, Qureshi IH, Rader DJ, Ralhan S, Rasheed A, Rasheed SZ, Reilly M, Ripatti S, Rizvi SNH, Rotter JI, Saghir T, Saleheen D, Salomaa V, Sanghera DK, Sapkota BR, Sattar N, Shah N, Sheu WH, Small A, Smit R, Surendran P, Tai ES, Tanveer-Us-Salam, Taylor KD, Teo YY, Tikkanen E, Trindade K, Tybjaerg-Hansen A, Voight BF, Wang TD, Yamauch T, Yaqoob Z, Young R, Zhang W, Zhao W |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1038/ng.3943">https://dx.doi.org/10.1038/ng.3943</a> |
Public note |
https://dx.doi.org/10.1038/ng.3943 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |