Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. (Record no. 2780)

MARC details
000 -LEADER
fixed length control field 03985nam a22005777a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170918s20172017 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1061-4036
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 28869590
245 ## - TITLE STATEMENT
Title Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
251 ## - Source
Source Nature Genetics. 49(10):1450-1457, 2017 Oct
252 ## - Abbreviated Source
Abbreviated source Nat Genet. 49(10):1450-1457, 2017 Oct
253 ## - Journal Name
Journal name Nature genetics
253 ## - Journal Name
Journal name Nature genetics
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2017
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2018
266 ## - Date added to catalog
Date added to catalog 2017-09-18
520 ## - SUMMARY, ETC.
Abstract To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Coronary Disease/ge [Genetics]
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Topical term or geographic name entry element *Diabetes Mellitus, Type 2/ge [Genetics]
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Topical term or geographic name entry element *Genome-Wide Association Study
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Topical term or geographic name entry element Asia/ep [Epidemiology]
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Topical term or geographic name entry element Asian Continental Ancestry Group/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Biomarkers
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Topical term or geographic name entry element Comorbidity
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronary Disease/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronary Disease/et [Etiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Diabetes Mellitus, Type 2/dt [Drug Therapy]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Diabetes Mellitus, Type 2/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Diabetes Mellitus, Type 2/et [Etiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Europe/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element European Continental Ancestry Group/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Loci/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Predisposition to Disease
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HLA-DRB5 Chains/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Metabolic Networks and Pathways/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Metabolic Syndrome X/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Metabolic Syndrome X/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Molecular Targeted Therapy
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mutation, Missense
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Polymorphism, Single Nucleotide
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Factors
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Institution MedStar Health Research Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Epstein, Stephen E
790 ## - Authors
All authors Abbas S, Ahmed N, Alam DS, Anand S, Asma S, Assimes TL, Benn M, Bottinger EP, Butterworth AS, Chambers JC, CHD Exome+ Consortium, Chen P, Chen YI, Chowdhury R, Chung RH, Damrauer S, Danesh J, Di Angelantonio E, EPIC-CVD Consortium, EPIC-Interact Consortium, Epstein S, Frikke-Schmidt R, Frossard P, Guo X, Howson JMM, Hsiung CA, Hsu CC, Hung YJ, Imamura M, Imran A, Iqbal W, Jabeen S, Juang JJ, Jukema JW, Kadowaki T, Kamstrup PR, Kooner JS, Kuo JZ, Lee IT, Lee JJ, Lee WJ, Liang KW, Loos RJF, Lu Y, Maeda S, Majeed F, Malik U, Mallick NH, Mehmood K, Mehra N, Melander O, Memon A, Memon FU, Michigan Biobank, Nielsen SF, Nordestgaard BG, Orho-Melander M, Pare G, Qamar N, Quertermous T, Qureshi IH, Rader DJ, Ralhan S, Rasheed A, Rasheed SZ, Reilly M, Ripatti S, Rizvi SNH, Rotter JI, Saghir T, Saleheen D, Salomaa V, Sanghera DK, Sapkota BR, Sattar N, Shah N, Sheu WH, Small A, Smit R, Surendran P, Tai ES, Tanveer-Us-Salam, Taylor KD, Teo YY, Tikkanen E, Trindade K, Tybjaerg-Hansen A, Voight BF, Wang TD, Yamauch T, Yaqoob Z, Young R, Zhang W, Zhao W
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1038/ng.3943">https://dx.doi.org/10.1038/ng.3943</a>
Public note https://dx.doi.org/10.1038/ng.3943
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
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          MedStar Authors Catalog MedStar Authors Catalog 09/18/2017   28869590 28869590 09/18/2017 09/18/2017 Journal Article

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