MARC details
| 000 -LEADER |
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| fixed length control field |
02890nam a22003377a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171110s20172017 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2052-4897 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
29081977 |
| 245 ## - TITLE STATEMENT |
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| Title |
Statin use and risk of developing diabetes: results from the Diabetes Prevention Program. |
| 251 ## - Source |
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| Source |
BMJ Open Diabetes Research & Care. 5(1):e000438, 2017 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
BMJ open diabetes res. care. 5(1):e000438, 2017 |
| 253 ## - Journal Name |
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| Journal name |
BMJ open diabetes research & care |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2017 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2018 |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2017-11-10 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: In this population at high risk for diabetes, we observed significantly higher rates of diabetes with statin therapy in all three treatment groups. Confounding by indication for statin use does not appear to explain this relationship. The effect of statins to increase diabetes risk appears to extend to populations at high risk for diabetes. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
OBJECTIVE: Several clinical trials of cardiovascular disease prevention with statins have reported increased risk of type 2 diabetes (T2DM) with statin therapy. However, participants in these studies were at relatively low risk for diabetes. Further, diabetes was often based on self-report and was not the primary outcome. It is unknown whether statins similarly modify diabetes risk in higher risk populations. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESEARCH DESIGN AND METHODS: During the Diabetes Prevention Program Outcomes Study (n=3234), the long-term follow-up to a randomized clinical trial of interventions to prevent T2DM, incident diabetes was assessed by annual 75g oral glucose tolerance testing and semiannual fasting glucose. Lipid profile was measured annually, with statin treatment determined by a participant's own physician outside of the protocol. Statin use was assessed at baseline and semiannual visits. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: At 10years, the cumulative incidence of statin initiation prior to diabetes diagnosis was 33%-37%among the randomized treatment groups (p=0.36). Statin use was associated with greater diabetes risk irrespective of treatment group, with pooled HR (95%CI) for incident diabetes of 1.36 (1.17 to 1.58). This risk was not materially altered by adjustment for baseline diabetes risk factors and potential confounders related to indications for statin therapy. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
TRIAL REGISTRATION NUMBER: NCT00038727; Results. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
PubMed-not-MEDLINE -- Not indexed |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Ratner, Robert E |
| 790 ## - Authors |
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| All authors |
Barrett-Connor E, Crandall JP, Foo S, Goldberg RB, Mather K, Rajpathak SN, Ratner R, Temprosa M, Watson K |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1136/bmjdrc-2017-000438">https://dx.doi.org/10.1136/bmjdrc-2017-000438</a> |
| Public note |
https://dx.doi.org/10.1136/bmjdrc-2017-000438 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
