MARC details
000 -LEADER |
fixed length control field |
03268nam a22004697a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
221213s20222022 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0092-8674 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1016/j.cell.2022.06.007 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
NIHMS1819979 [mid] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
PMC9677434 [pmc] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
S0092-8674(22)00712-7 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
35803246 |
245 ## - TITLE STATEMENT |
Title |
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. |
251 ## - Source |
Source |
Cell. 185(14):2591-2608.e30, 2022 07 07. |
252 ## - Abbreviated Source |
Abbreviated source |
Cell. 185(14):2591-2608.e30, 2022 07 07. |
253 ## - Journal Name |
Journal name |
Cell |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2023 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2022 07 07 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Medline status |
MEDLINE |
266 ## - Date added to catalog |
Date added to catalog |
2022-12-13 |
520 ## - SUMMARY, ETC. |
Abstract |
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant intra-tumoral B to plasma cell differentiation in lymphoid aggregates in MBM. MBM harbored larger fractions of monocyte-derived macrophages and dysfunctional TOX+CD8+ T cells with distinct expression of immune checkpoints. This work provides comprehensive insights into MBM biology and serves as a foundational resource for further discovery and therapeutic exploration. Copyright © 2022 Elsevier Inc. All rights reserved. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Brain Neoplasms |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Melanoma |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Brain Neoplasms/dt [Drug Therapy] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Brain Neoplasms/sc [Secondary] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
CD8-Positive T-Lymphocytes/pa [Pathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Ecosystem |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
RNA-Seq |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
Washington Cancer Institute |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Research Support, N.I.H., Extramural |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Research Support, Non-U.S. Gov't |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Rapisuwon, Suthee |
790 ## - Authors |
All authors |
Agrawal P, Agustinus A, Amin AD, Andreatta M, Atkins MB, Azizi E, Bakhoum SF, Banu M, Barrera I, Berhe S, Bi WL, Biermann J, Bruce JN, Caldwell B, Canoll P, Caprio LA, Carmona SJ, Carvajal R, Chazotte M, Chen F, Davies MA, Driver J, Eigentler T, Fullerton BT, Gretarsson KH, Hernando E, Hibshoosh H, Ho P, Humala N, Ibarra-Arellano MA, Ingham M, Izar B, Karz A, Khan SA, Koch PD, Lu C, Luoma AM, Macosko EZ, Mahajan A, Mangipudy VS, Melms JC, Mu M, Nair A, Nguyen TTT, Rapisuwon S, Ribas A, Rocken M, Rogava M, Sahu V, Schapiro D, Schwartz GK, Shah SB, Siegelin M, Slingluff CL Jr, Tagore S, Vaccaro DH, Walsh ZH, Wang Y, Wunnemann F |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1016/j.cell.2022.06.007">https://dx.doi.org/10.1016/j.cell.2022.06.007</a> |
Public note |
https://dx.doi.org/10.1016/j.cell.2022.06.007 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |