Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. (Record no. 29)

MARC details
000 -LEADER
fixed length control field 03268nam a22004697a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 221213s20222022 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0092-8674
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.cell.2022.06.007 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code NIHMS1819979 [mid]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC9677434 [pmc]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S0092-8674(22)00712-7 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 35803246
245 ## - TITLE STATEMENT
Title Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
251 ## - Source
Source Cell. 185(14):2591-2608.e30, 2022 07 07.
252 ## - Abbreviated Source
Abbreviated source Cell. 185(14):2591-2608.e30, 2022 07 07.
253 ## - Journal Name
Journal name Cell
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2023
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2022 07 07
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Medline status MEDLINE
266 ## - Date added to catalog
Date added to catalog 2022-12-13
520 ## - SUMMARY, ETC.
Abstract Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant intra-tumoral B to plasma cell differentiation in lymphoid aggregates in MBM. MBM harbored larger fractions of monocyte-derived macrophages and dysfunctional TOX+CD8+ T cells with distinct expression of immune checkpoints. This work provides comprehensive insights into MBM biology and serves as a foundational resource for further discovery and therapeutic exploration. Copyright © 2022 Elsevier Inc. All rights reserved.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Brain Neoplasms
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Melanoma
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Brain Neoplasms/dt [Drug Therapy]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Brain Neoplasms/sc [Secondary]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CD8-Positive T-Lymphocytes/pa [Pathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ecosystem
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RNA-Seq
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution Washington Cancer Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, N.I.H., Extramural
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, Non-U.S. Gov't
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Rapisuwon, Suthee
790 ## - Authors
All authors Agrawal P, Agustinus A, Amin AD, Andreatta M, Atkins MB, Azizi E, Bakhoum SF, Banu M, Barrera I, Berhe S, Bi WL, Biermann J, Bruce JN, Caldwell B, Canoll P, Caprio LA, Carmona SJ, Carvajal R, Chazotte M, Chen F, Davies MA, Driver J, Eigentler T, Fullerton BT, Gretarsson KH, Hernando E, Hibshoosh H, Ho P, Humala N, Ibarra-Arellano MA, Ingham M, Izar B, Karz A, Khan SA, Koch PD, Lu C, Luoma AM, Macosko EZ, Mahajan A, Mangipudy VS, Melms JC, Mu M, Nair A, Nguyen TTT, Rapisuwon S, Ribas A, Rocken M, Rogava M, Sahu V, Schapiro D, Schwartz GK, Shah SB, Siegelin M, Slingluff CL Jr, Tagore S, Vaccaro DH, Walsh ZH, Wang Y, Wunnemann F
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1016/j.cell.2022.06.007">https://dx.doi.org/10.1016/j.cell.2022.06.007</a>
Public note https://dx.doi.org/10.1016/j.cell.2022.06.007
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 12/13/2022   35803246 35803246 12/13/2022 12/13/2022 Journal Article

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