Testing the product of slopes in related regressions. (Record no. 3289)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02147nam a22002777a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180508s20132013 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0972-3617 |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | NIHMS520123 [mid] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | PMC4206214 [pmc] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 25346580 |
| 245 ## - TITLE STATEMENT | |
| Title | Testing the product of slopes in related regressions. |
| 251 ## - Source | |
| Source | Advances & Applications in Statistics. 36(1):29-46, 2013 Sep 01 |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Adv. Appl. Stat.. 36(1):29-46, 2013 Sep 01 |
| 253 ## - Journal Name | |
| Journal name | Advances and applications in statistics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2013 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2014 |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2018-05-08 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | A study was conducted of the relationships among neuroprotective factors and cytokines in brain tissue of mice at different ages that were examined on the effect of dietary restriction on protection after experimentally induced brain stroke. It was of interest to assess whether the cross-product of the slopes of pairs of variables vs. age was positive or negative. To accomplish this, the product of the slopes was estimated and tested to determine if it is significantly different from zero. Since the measurements are taken on the same animals, the models used must account for the non-independence of the measurements within animals. A number of approaches are illustrated. First a multivariate multiple regression model is employed. Since we are interested in a nonlinear function of the parameters (the product) the delta method is used to obtain the standard error of the estimate of the product. Second, a linear mixed-effects model is fit that allows for the specification of an appropriate correlation structure among repeated measurements. The delta method is again used to obtain the standard error. Finally, a non-linear mixed-effects approach is taken to fit the linear-mixed-effects model and conduct the test. A simulation study investigates the properties of the procedure. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Shetty, Veena |
| 790 ## - Authors | |
| All authors | Arumugam TV, Mattson MP, Morrell CH, Phillips T, Shetty V, Wan R |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 05/08/2018 | 25346580 | 25346580 | 05/08/2018 | 05/08/2018 | Journal Article |