MARC details
| 000 -LEADER |
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| fixed length control field |
04471nam a22006017a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180619s20182018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1355-008X |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s12020-018-1636-y [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s12020-018-1636-y [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
29797211 |
| 245 ## - TITLE STATEMENT |
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| Title |
Use of <sup>99m</sup>Tc-sestamibi SPECT/CT when conventional imaging studies are negative for localizing suspected recurrence in differentiated thyroid cancer: a method and a lesson for clinical management. |
| 251 ## - Source |
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| Source |
Endocrine. 62(1):57-63, 2018 10. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Endocrine. 62(1):57-63, 2018 10. |
| 253 ## - Journal Name |
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| Journal name |
Endocrine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2018 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2018-06-19 |
| 269 ## - Original dates |
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| Original fiscal year |
FY2018 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: <sup>99m</sup>Tc-sestamibi may have a role in thyroid cancer localization when physical exam, neck ultrasound, radioiodine scan, chest/abdomen CT, and <sup>18</sup>F-FDG PET/CT does not identify the source of elevated Tg levels in DTC. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PATIENT AND METHODS: A 73-year-old woman was referred for widely-invasive metastatic follicular thyroid cancer with bone metastasis to her left mandible. She had a total thyroidectomy, left mandibular resection, and <sup>131</sup>I therapy of 145mCi (5.4GBq) and her subsequent unstimulated serum Tg level was 29ng/ml (TgAb negative). At six months' follow-up, her stimulated Tg was 527ng/ml (TSH 188mIU/L, TgAb negative). All imaging studies performed within the prior 12 months were reported as negative for recurrence or metastasis; this included neck ultrasound, diagnostic radioiodine scan, chest CT and, <sup>18</sup>F-FDG PET/CT. The patient was injected with 24.6mCi (910MBq) of <sup>99m</sup>Tc-sestamibi intravenously, and whole-body and SPECT/CT images were acquired. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PURPOSE: The detection of recurrent disease in differentiated thyroid cancer (DTC) patients with elevated or rising serum thyroglobulin (Tg) levels and multiple negative conventional imaging studies can be challenging, especially when <sup>18</sup>F-FDG PET/CT scan is also negative. We report a patient and review the literature on the diagnostic use of <sup>99m</sup>Tc-sestamibi scans to identify the source of elevated or rising Tg in patients with negative conventional imaging including negative <sup>18</sup>F-FDG PET/CT scans. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: The <sup>99m</sup>Tc-sestamibi whole-body posterior image demonstrated abnormal focal uptake in the right posterior calvarium and corresponded to an occipital lytic bone lesion on the SPECT/CT. The patient underwent surgical resection of the skull metastasis, and pathology confirmed metastatic follicular thyroid cancer. Five months post-surgery, the suppressed Tg was markedly reduced and remained stable at ~3.2ng/ml. With the knowledge of the DTC recurrence location, the two sets of <sup>18</sup>F-FDG images were re-evaluated. The more thorough and targeted interpretation underscored the importance of structured image reporting. The current literature on the utility of <sup>99m</sup>Tc-sestamibi scans when radioiodine, <sup>18</sup>F-FDG PET/CT, and other imaging studies are negative is sparse and inconsistent. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Adenocarcinoma, Follicular/dg [Diagnostic Imaging] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Single Photon Emission Computed Tomography Computed Tomography |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Thyroglobulin/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Thyroid Neoplasms/dg [Diagnostic Imaging] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adenocarcinoma, Follicular/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adenocarcinoma, Follicular/su [Surgery] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Technetium Tc 99m Sestamibi |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Thyroid Neoplasms/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Thyroid Neoplasms/su [Surgery]=790 \\ |
| -- |
Wu D |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Endocrinology |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Nuclear Medicine |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Pathology |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Burman, Kenneth D |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Gomes Lima, Cristiane J |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Lee, Wen |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Van Nostrand, Douglas |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Wartofsky, Leonard |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Wu, Di |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Ylli, Dorina |
| 790 ## - Authors |
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| All authors |
Burman KD, Gomes Lima CJ, Lee W, Van Nostrand D, Wartofsky L, Ylli D |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1007/s12020-018-1636-y">https://dx.doi.org/10.1007/s12020-018-1636-y</a> |
| Public note |
https://dx.doi.org/10.1007/s12020-018-1636-y |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
