MARC details
000 -LEADER |
fixed length control field |
03216nam a22003377a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
220926s20222022 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0085-2538 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1016/j.kint.2022.06.023 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
S0085-2538(22)00536-1 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
35853479 |
245 ## - TITLE STATEMENT |
Title |
Lipidomic profiling in the Strong Heart Study identified American Indians at risk of chronic kidney disease. |
251 ## - Source |
Source |
Kidney International. 2022 Jul 16 |
252 ## - Abbreviated Source |
Abbreviated source |
Kidney Int. 2022 Jul 16 |
253 ## - Journal Name |
Journal name |
Kidney international |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2023 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2022 Jul 16 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
aheadofprint |
266 ## - Date added to catalog |
Date added to catalog |
2022-09-26 |
501 ## - WITH NOTE |
Local holdings |
Available online from MWHC library: 1972 - present, Available in print through MWHC library: 1999 - 2006 |
520 ## - SUMMARY, ETC. |
Abstract |
Dyslipidemia associates with and usually precedes the onset of chronic kidney disease (CKD), but a comprehensive assessment of molecular lipid species associated with risk of CKD is lacking. Here, we sought to identify fasting plasma lipids associated with risk of CKD among American Indians in the Strong Heart Family Study, a large-scale community-dwelling of individuals, followed by replication in Mexican Americans from the San Antonio Family Heart Study and Caucasians from the Australian Diabetes, Obesity and Lifestyle Study. We also performed repeated measurement analysis to examine the temporal relationship between the change in the lipidome and change in kidney function between baseline and follow-up of about five years apart. Network analysis was conducted to identify differential lipid classes associated with risk of CKD. In the discovery cohort, we found that higher baseline level of multiple lipid species, including glycerophospholipids, glycerolipids and sphingolipids, was significantly associated with increased risk of CKD, independent of age, sex, body mass index, diabetes and hypertension. Many lipid species were replicated in at least one external cohort at the individual lipid species and/or the class level. Longitudinal change in the plasma lipidome was significantly associated with change in the estimated glomerular filtration rate after adjusting for covariates, baseline lipids and the baseline rate. Network analysis identified distinct lipidomic signatures differentiating high from low-risk groups. Thus, our results demonstrated that disturbed lipid metabolism precedes the onset of CKD. These findings shed light on the mechanisms linking dyslipidemia to CKD and provide potential novel biomarkers for identifying individuals with early impaired kidney function at preclinical stages. Copyright © 2022 International Society of Nephrology. All rights reserved. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Health Research Institute |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Umans, Jason G |
790 ## - Authors |
All authors |
Beyene HB, Blangero J, Cole SA, Curran JE, Fiehn O, Franceschini N, Howard BV, Kuokkanen M, Lee ET, Magliano DJ, Meikle PJ, Miao G, Michailidis G, Umans JG, Zeng W, Zhao J |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1016/j.kint.2022.06.023">https://dx.doi.org/10.1016/j.kint.2022.06.023</a> |
Public note |
https://dx.doi.org/10.1016/j.kint.2022.06.023 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |